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Title

CURCUMIN AND QUERCETIN AMELIORATED CYPERMETHRIN AND DELTAMETHRIN-INDUCED REPRODUCTIVE SYSTEM IMPAIRMENT IN MALE WISTAR RATS BY UPREGULATING THE ACTIVITY OF PITUITARY-GONADAL HORMONES AND STEROIDOGENIC ENZYMES

Pages

  72-80

Abstract

 Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, CYPERMETHRIN (Cyp) and DELTAMETHRIN (Del) and possible protective effects of CURCUMIN and QUERCETIN on reproductive systemin male Wistar rats.Materials and Methods: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7groups of 6 animals. Group A served as control, group B was exposed to Cyp (2 mg/kg.bw), group C was exposedto Del (2 mg/kg.bw), group D was exposed to Cyp+Del (2 mg/kg.bw each), group E was exposed to Cyp+Del and treated with CURCUMIN (100 mg/kg.bw), group F was exposed to Cyp+Del and treated with QUERCETIN (100 mg/kg.bw) and group G was exposed to Cyp+Del and treated with QUERCETIN+CURCUMIN for 45 days.Results: Exposure to Cyp and Del caused decreases in reproductive organs weight, sperm count, sperm motility, level of sex hormones viz. testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH), steroidogenic enzymes viz.3b-hydroxyl steroid dehydrogenase (3b-HSD) and 17b-HSD, non-enzymatic antioxidant glutathione (GSH) and enzymatic antioxidants viz. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) activity and increases in sperm abnormalities and lipid peroxidation (LPO). The exposure also adversely affected the histo-achitecture of testes. Single and combined treatment with CURCUMIN and QUERCETIN significantly ameliorated Cyp and Del-induced damagein reproductive system.Conclusion: CURCUMIN and QUERCETIN protected against Cyp and Del-induced reproductive system toxicity andoxidative damage in rats. The increases in activities of 3b-HSD and 17b-HSD with concomitant increases in testosterone were mainly responsible for ameliorating effects of CURCUMIN and QUERCETIN. CURCUMIN showed slightly better activity as compared to QUERCETIN. The combination of both antioxidants offered more protection compared to each one alone.

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    APA: Copy

    SHARMA, POONAM, ASLAM KHAN, IRSHAD, & SINGH, RAMBIR. (2018). CURCUMIN AND QUERCETIN AMELIORATED CYPERMETHRIN AND DELTAMETHRIN-INDUCED REPRODUCTIVE SYSTEM IMPAIRMENT IN MALE WISTAR RATS BY UPREGULATING THE ACTIVITY OF PITUITARY-GONADAL HORMONES AND STEROIDOGENIC ENZYMES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(1), 72-80. SID. https://sid.ir/paper/305966/en

    Vancouver: Copy

    SHARMA POONAM, ASLAM KHAN IRSHAD, SINGH RAMBIR. CURCUMIN AND QUERCETIN AMELIORATED CYPERMETHRIN AND DELTAMETHRIN-INDUCED REPRODUCTIVE SYSTEM IMPAIRMENT IN MALE WISTAR RATS BY UPREGULATING THE ACTIVITY OF PITUITARY-GONADAL HORMONES AND STEROIDOGENIC ENZYMES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(1):72-80. Available from: https://sid.ir/paper/305966/en

    IEEE: Copy

    POONAM SHARMA, IRSHAD ASLAM KHAN, and RAMBIR SINGH, “CURCUMIN AND QUERCETIN AMELIORATED CYPERMETHRIN AND DELTAMETHRIN-INDUCED REPRODUCTIVE SYSTEM IMPAIRMENT IN MALE WISTAR RATS BY UPREGULATING THE ACTIVITY OF PITUITARY-GONADAL HORMONES AND STEROIDOGENIC ENZYMES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 1, pp. 72–80, 2018, [Online]. Available: https://sid.ir/paper/305966/en

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