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Title

DECREASED EXPRESSION OF ARGININE-PHENYLALANINE-AMIDE-RELATEDPEPTIDE-3 GENE IN DORSOMEDIAL HYPOTHALAMIC NUCLEUS OF CONSTANT LIGHT EXPOSURE MODEL OF POLYCYSTIC OVARIAN SYNDROME

Pages

  43-50

Abstract

 Background: An abnormality in pulse amplitude and frequency of gonadotropin releasing hormone (GnRH) secretion is the most characteristics of polycystic ovarian syndrome (PCOS). On the other hand, arginine-phenylalanine-amide (RFamide) -related peptide-3 (RFRP3) inhibits the secretion of GnRH in mammalian hypothalamus. The current study performed in order to investigate the expression of RFRP3 mRNA in the DORSOMEDIAL HYPOTHALAMIC NUCLEUS (DMH)after the induction of PCOS in a rat model of CONSTANT LIGHT exposure, and the possible role of parity on occurrence of PCOS.Materials and Methods: In the experimental study, female nulliparous (n=12) and primiparous (n=12) RATS were randomly subdivided into control and PCOS subgroups (n=6). PCOS were induced by 90 days exposure to CONSTANT LIGHT. After 90 days, blood, brain, and ovaries were sampled. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone were evaluated. In addition, six adult female ovariectomized RATS as a control of real-time polymerase chain reaction (PCR) tests were prepared and in the DMH of all RATS, the relative mRNA expression of RFRP3 was assessed.Results: Histological evaluation of ovaries represented the polycystic features. In addition, serum concentrations of testosterone in the PCOS subgroups were more than the controls (P<0.05). Furthermore, the relative expression ofRFRP3 mRNA in PCOS subgroups was lower than the controls (P<0.05).Conclusion: CONSTANT LIGHT model of the PCOS-induced RATS decreased the gene expression of RFRP3 in the DMH that suggests the decrease of RFRP3 may reduce its inhibitory effect on GnRH during the PCOS pathogenesis. This effect was stronger in the nulliparous RATS than the primiparous.

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    APA: Copy

    SHAABAN, ZAHRA, JAFARZADEH SHIRAZI, MOHAMMAD REZA, NOORANIZADEH, MOHAMMAD HOSSEIN, TAMADON, AMIN, RAHMANIFAR, FARHAD, AHMADLOO, SOMAYEH, RAMEZANI, AMIN, ZAMIRI, MOHAMMAD JAVAD, Razeghian Jahromi, Iman, SABET SARVESTANI, FATEMEH, & KOOHI HOSSEINABADI, OMID. (2018). DECREASED EXPRESSION OF ARGININE-PHENYLALANINE-AMIDE-RELATEDPEPTIDE-3 GENE IN DORSOMEDIAL HYPOTHALAMIC NUCLEUS OF CONSTANT LIGHT EXPOSURE MODEL OF POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(1), 43-50. SID. https://sid.ir/paper/305968/en

    Vancouver: Copy

    SHAABAN ZAHRA, JAFARZADEH SHIRAZI MOHAMMAD REZA, NOORANIZADEH MOHAMMAD HOSSEIN, TAMADON AMIN, RAHMANIFAR FARHAD, AHMADLOO SOMAYEH, RAMEZANI AMIN, ZAMIRI MOHAMMAD JAVAD, Razeghian Jahromi Iman, SABET SARVESTANI FATEMEH, KOOHI HOSSEINABADI OMID. DECREASED EXPRESSION OF ARGININE-PHENYLALANINE-AMIDE-RELATEDPEPTIDE-3 GENE IN DORSOMEDIAL HYPOTHALAMIC NUCLEUS OF CONSTANT LIGHT EXPOSURE MODEL OF POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(1):43-50. Available from: https://sid.ir/paper/305968/en

    IEEE: Copy

    ZAHRA SHAABAN, MOHAMMAD REZA JAFARZADEH SHIRAZI, MOHAMMAD HOSSEIN NOORANIZADEH, AMIN TAMADON, FARHAD RAHMANIFAR, SOMAYEH AHMADLOO, AMIN RAMEZANI, MOHAMMAD JAVAD ZAMIRI, Iman Razeghian Jahromi, FATEMEH SABET SARVESTANI, and OMID KOOHI HOSSEINABADI, “DECREASED EXPRESSION OF ARGININE-PHENYLALANINE-AMIDE-RELATEDPEPTIDE-3 GENE IN DORSOMEDIAL HYPOTHALAMIC NUCLEUS OF CONSTANT LIGHT EXPOSURE MODEL OF POLYCYSTIC OVARIAN SYNDROME,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 1, pp. 43–50, 2018, [Online]. Available: https://sid.ir/paper/305968/en

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