OPTIMAL DURATION OF TREATMENT FOR HCV GENOTYPE 1 INFECTION IN SLOW RESPONDERS: A META-ANALYSIS

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ALAVIAN SEYED MOAYED; TABATABAEI SEYED VAHID; BEHNAVA BITA; MAHBOOBI NASTARAN

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Journal Paper

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Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:8 (37) Page(s): 612-619

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Information Journal Paper

Title

OPTIMAL DURATION OF TREATMENT FOR HCV GENOTYPE 1 INFECTION IN SLOW RESPONDERS: A META-ANALYSIS

Author(s)

ALAVIAN SEYED MOAYED | TABATABAEI SEYED VAHID | BEHNAVA BITA | MAHBOOBI NASTARAN | Issue Writer Certificate

Keywords

HEPATITIS C VIRUS

GENOTYPE

TREATMENTS

Abstract

Background: A head-to-head comparison of the 72-week and 48-week anti-HCV therapies in slow responders with GENOTYPE 1 infection has been performed in several randomized clinical trials (RCTs).Objectives: This review aimed at summarizing and pooling the results of these studies.Materials and Methods: RCTs that had evaluated the 72-week vs.48-week anti-HCV therapy (peginterferon and ribavirin) in slow responders with HCV GENOTYPE 1 infection were systematically identified. A meta-analysis was performed using the random effects model. Heterogeneity in results was assessed on the basis of the Q statistics, and publication bias was evaluated by using Harbord’s modified test. The end point was set as a sustained virological response (SVR).Results: Data of 1206 subjects were retrieved from 7 studies. A total of 631 patients had received extended therapy. Slow virological responders who received the 72-week therapy had a significantly higher probability of achieving SVR than their counterparts who received the 48-week therapy [RR=1.44 (95% CI, 1.20–1.73)]. With regard to publication biases, the heterogeneity in funnel plots was not significant (P=0.19, I2=30%, PHarbord=0.1).Conclusion: Our meta-analysis showed that the 72-week therapy with peginterferon and ribavirin is significantly superior to the standard 48-week therapy in slow responders with HCV GENOTYPE 1 infection.

Cites

EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY

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APA: Copy

ALAVIAN, SEYED MOAYED, TABATABAEI, SEYED VAHID, BEHNAVA, BITA, & MAHBOOBI, NASTARAN. (2011). OPTIMAL DURATION OF TREATMENT FOR HCV GENOTYPE 1 INFECTION IN SLOW RESPONDERS: A META-ANALYSIS. HEPATITIS MONTHLY, 11(8 (37)), 612-619. SID. https://sid.ir/paper/306440/en

Vancouver: Copy

ALAVIAN SEYED MOAYED, TABATABAEI SEYED VAHID, BEHNAVA BITA, MAHBOOBI NASTARAN. OPTIMAL DURATION OF TREATMENT FOR HCV GENOTYPE 1 INFECTION IN SLOW RESPONDERS: A META-ANALYSIS. HEPATITIS MONTHLY[Internet]. 2011;11(8 (37)):612-619. Available from: https://sid.ir/paper/306440/en

IEEE: Copy

SEYED MOAYED ALAVIAN, SEYED VAHID TABATABAEI, BITA BEHNAVA, and NASTARAN MAHBOOBI, “OPTIMAL DURATION OF TREATMENT FOR HCV GENOTYPE 1 INFECTION IN SLOW RESPONDERS: A META-ANALYSIS,” HEPATITIS MONTHLY, vol. 11, no. 8 (37), pp. 612–619, 2011, [Online]. Available: https://sid.ir/paper/306440/en

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