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Title

MYSTERIOUS LINKAGES BETWEEN HEPATITIS C VIRUS GENOTYPES, INTERLEUKIN-28B GENOTYPES AND VIRAL CLEARANCE- A META-ANALYSIS

Pages

  1-8

Abstract

 Background: Recent genome wide association studies (GWAS) have shown important roles of single nucleotide polymorphisms (SNP) near region of interleukin B 28 (IL28B) gene in spontaneous and drug-induced clearance of HEPATITIS C virus (HCV) in GENOTYPE 1 HCV infection.Objectives: This META-ANALYSIS was designed to determine the world-wide distribution patterns of IL28B GENOTYPEs and alleles, and to find possible linkages between IL28B and HCV GENOTYPEs.Patients and Methods: Manual and electronic databases were searched. Critical appraisal was performed. According to the results of heterogeneity tests, we used fix/random model for the analysis. The data concerning patients’ ethnicity and HCV GENOTYPEs were analyzed by using statistical analysis software.Results: A total of 255 articles were found. After article review and quality assessment, 50 studies, including 18662 patients and 1313 healthy subjects, were analyzed. Presence of HCV GENOTYPE 3 versus GENOTYPE 1 was significantly associated with a higher frequency of CC GENOTYPE and C allele, with an odds ratio (OR) of 1.68 (95% CI: 1.44-1.99) and 1.49 (95% CI: 1.33-1.67), respectively. Prevalence of the rs12979860 CC GENOTYPE among GENOTYPE 1 HCV infected patients of Asian ethnicity was 69.48% (95% CI: 65.20-73.77), which was significantly higher than its prevalence [33.27% (95% CI: 28.88-37.67)] in the Caucasian GENOTYPE 1 HCV infected patients. Prevalence of rs12979860 TT GENOTYPE in the African-American GENOTYPE 1 HCV infected patients was the highest [36.20% (95% CI: 32.91-39.49)], and significantly different compared to all other ethnicities.Conclusions: There were significant linkages between HCV GENOTYPEs and IL28B GENOTYPEs/alleles. Patients with a favorable IL28B and GENOTYPEs 1 and 4 HCV infection stand a better chance to clear HCV in the acute phase.

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    APA: Copy

    AALAEI ANDABILI, SEYED HOSSEIN, BEHNAVA, BITA, SALIMI, SHIMA, SHARAFI, HEIDAR, & ALAVIAN, SEYED MOAYED. (2014). MYSTERIOUS LINKAGES BETWEEN HEPATITIS C VIRUS GENOTYPES, INTERLEUKIN-28B GENOTYPES AND VIRAL CLEARANCE- A META-ANALYSIS. HEPATITIS MONTHLY, 14(3), 1-8. SID. https://sid.ir/paper/306573/en

    Vancouver: Copy

    AALAEI ANDABILI SEYED HOSSEIN, BEHNAVA BITA, SALIMI SHIMA, SHARAFI HEIDAR, ALAVIAN SEYED MOAYED. MYSTERIOUS LINKAGES BETWEEN HEPATITIS C VIRUS GENOTYPES, INTERLEUKIN-28B GENOTYPES AND VIRAL CLEARANCE- A META-ANALYSIS. HEPATITIS MONTHLY[Internet]. 2014;14(3):1-8. Available from: https://sid.ir/paper/306573/en

    IEEE: Copy

    SEYED HOSSEIN AALAEI ANDABILI, BITA BEHNAVA, SHIMA SALIMI, HEIDAR SHARAFI, and SEYED MOAYED ALAVIAN, “MYSTERIOUS LINKAGES BETWEEN HEPATITIS C VIRUS GENOTYPES, INTERLEUKIN-28B GENOTYPES AND VIRAL CLEARANCE- A META-ANALYSIS,” HEPATITIS MONTHLY, vol. 14, no. 3, pp. 1–8, 2014, [Online]. Available: https://sid.ir/paper/306573/en

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