REAL RESPONSE TO THERAPY IN CHRONIC HEPATITIS C VIRUS PATIENTS: A STUDY FROM IRAN

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NAMAZEE NAJMEH; SALI SHAHNAZ; ASADI SOROUR; SHAFIEI MOSTAFA; BEHNAVA BITA; ALAVIAN SEYED MOAYED

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:9 Page(s): 1-8

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Title

REAL RESPONSE TO THERAPY IN CHRONIC HEPATITIS C VIRUS PATIENTS: A STUDY FROM IRAN

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Keywords

HEPATITIS C

CHRONIC

PEGINTERFERON ALFA-2A

RIBAVIRIN

Abstract

Background: Despite significant advances in the treatment of CHRONIC HEPATITIS C in the past decades, factors which can affect response rates to combination therapy; peginterferon and RIBAVIRIN, are still under study and reaching sustained virological response (SVR) is affected by several different factors.Objectives: To investigate predictor factors contributing to SVR in Iranian patients.Patients and Methods: The present non-randomized, clinical trial was conducted on 100 patients referred to the Tehran HEPATITIS Center in 2009-2011. The patients were administered combined peginterferon a-2a-ribavirin treatment, based on the standard protocol of the Iranian Ministry of Health. At the end of the treatment, the SVR rate and predictors were evaluated.Results: The mean age of the patients was 42 and 78% were male. Genotype 1a was the most common (70%) and 55% of patients were treatment naive. The outcomes showed that 12%, 16% and 22% patients were; non-responders, breakthroughs and relapsers, respectively, while 50% of the patients reached SVR. Patients reaching SVR were aged 40 years or lower, they were less likely to have been a non-responder in prior treatments, more likely to have a non-1a genotype and a higher number had an HCV RNA of less than 600 000 IU/ml. The multivariate analysis showed that an age of 40 or lower (OR=3.74, CI95%=1.52-9.22), a non-1a genotype (OR=3.71, CI 95%=1.40-9.81) and an HCV RNA less than 600 000 IU/ml (OR=2.52, CI 95%=1.03-6.15) may be useful SVR predictors.Conclusions: The findings of the present study showed that half of the patients reached SVR through combined peginterferon a-2a and RIBAVIRIN treatment, the majority of whom had genotype 3a and a minority had genotype 1a. In addition, an age of 40 or lower, non-1a genotype and a viral load less than 600 000 IU/ml were strong SVR predictors

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APA: Copy

NAMAZEE, NAJMEH, SALI, SHAHNAZ, ASADI, SOROUR, SHAFIEI, MOSTAFA, BEHNAVA, BITA, & ALAVIAN, SEYED MOAYED. (2012). REAL RESPONSE TO THERAPY IN CHRONIC HEPATITIS C VIRUS PATIENTS: A STUDY FROM IRAN. HEPATITIS MONTHLY, 12(9), 1-8. SID. https://sid.ir/paper/306823/en

Vancouver: Copy

NAMAZEE NAJMEH, SALI SHAHNAZ, ASADI SOROUR, SHAFIEI MOSTAFA, BEHNAVA BITA, ALAVIAN SEYED MOAYED. REAL RESPONSE TO THERAPY IN CHRONIC HEPATITIS C VIRUS PATIENTS: A STUDY FROM IRAN. HEPATITIS MONTHLY[Internet]. 2012;12(9):1-8. Available from: https://sid.ir/paper/306823/en

IEEE: Copy

NAJMEH NAMAZEE, SHAHNAZ SALI, SOROUR ASADI, MOSTAFA SHAFIEI, BITA BEHNAVA, and SEYED MOAYED ALAVIAN, “REAL RESPONSE TO THERAPY IN CHRONIC HEPATITIS C VIRUS PATIENTS: A STUDY FROM IRAN,” HEPATITIS MONTHLY, vol. 12, no. 9, pp. 1–8, 2012, [Online]. Available: https://sid.ir/paper/306823/en

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