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Title

CHRONIC HEPATITIS C IN SAUDI ARABIA: THREE YEARS LOCAL EXPERIENCE IN A UNIVERSITY HOSPITAL

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  1-6

Abstract

 Background: CHRONIC HEPATITIS C (CHC) is a global infection. In SAUDI ARABIA, the prevalence of CHC is declining due to the implementation of a blood screening program. However, CHC still remains a leading cause of LIVER CIRRHOSIS and HEPATOCELLULAR CARCINOMA.Objectives: This is a retrospective study of CHC patients at the King Abdul Aziz University Hospital, Jeddah, SAUDI ARABIA.Patients and Methods: Out of a total of 291 CHC patients from the hepatology clinic at King Abdul Aziz University hospital, Jeddah, 279 patients were included in the present study. They were primarily male (152, 54.5%), with a mean age of 50.41±1.72 years. The majority of patients were either Saudi (108, 38.7%) or Egyptian (60, 21.5%). A total of 61 patients received combination treatment with pegylated interferon and RIBAVIRIN, and one patient with sickle-cell anemia received pegylated INF monotherapy. Demographic, clinical and laboratory features of the CHC patients, and their responses to treatment were studied.Results: Decompensated cirrhosis was documented in 60 patients (21.5%), and HEPATOCELLULAR CARCINOMA in 14 (5%). The mean level of serum alanine aminotransferase was 83.6±231 u/L. The predominant genotype among the 70 patients tested, was genotype 4, followed by genotype 1 (39 and 18 patients, respectively). The sustained viral response (SVR) rate was 82.99%. The main predictive factors for SVR were baseline HCV viral load and rapid virologic response (RVR). The mean duration of follow-up was 4.2±.85 years. There were 24 patients who had liver disease-related mortality.Conclusions: our data showed that 22% of CHC patients progress to cirrhosis and another 22% had treatment. Liver related mortality was more common in patients with advanced cirrhosis.

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    APA: Copy

    AKBAR, HISHAM O, GHAMDI, AHMAD AL, QATTAN, FATEN, FALLATAH, HIND I, & RUMANI, MAHA AL. (2012). CHRONIC HEPATITIS C IN SAUDI ARABIA: THREE YEARS LOCAL EXPERIENCE IN A UNIVERSITY HOSPITAL. HEPATITIS MONTHLY, 12(9), 1-6. SID. https://sid.ir/paper/306827/en

    Vancouver: Copy

    AKBAR HISHAM O, GHAMDI AHMAD AL, QATTAN FATEN, FALLATAH HIND I, RUMANI MAHA AL. CHRONIC HEPATITIS C IN SAUDI ARABIA: THREE YEARS LOCAL EXPERIENCE IN A UNIVERSITY HOSPITAL. HEPATITIS MONTHLY[Internet]. 2012;12(9):1-6. Available from: https://sid.ir/paper/306827/en

    IEEE: Copy

    HISHAM O AKBAR, AHMAD AL GHAMDI, FATEN QATTAN, HIND I FALLATAH, and MAHA AL RUMANI, “CHRONIC HEPATITIS C IN SAUDI ARABIA: THREE YEARS LOCAL EXPERIENCE IN A UNIVERSITY HOSPITAL,” HEPATITIS MONTHLY, vol. 12, no. 9, pp. 1–6, 2012, [Online]. Available: https://sid.ir/paper/306827/en

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