TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE)

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TAVAKOLPOUR SOHEIL; SALI SHAHNAZ

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Journal: Hepatitis Monthly Year:2016 | Volume:16 | Issue:4 Page(s): 0-0

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Title

TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE)

Author(s)

TAVAKOLPOUR SOHEIL | SALI SHAHNAZ | Issue Writer Certificate

Keywords

TUMOR NECROSIS FACTOR-α

HEPATOCELLULAR CARCINOMA

POLYMORPHISMS

TNF-α 308

META-ANALYSIS

Abstract

Context: HEPATOCELLULAR CARCINOMA (HCC) is a common disorder throughout the world that can develop due to various factors, including genetics. Tumor necrosis factor-a(TNF-a) is the most frequently studied cytokine related to the risk of developing HCC, and an association between the 308 position of the TNF-a promoter (TNFa-308) and HCCrisk has been confirmed in various reports.Evidence Acquisition: The PubMed, Scopus, and Google Scholar databases were searched through July 12, 2015, for studies on associations between TNF-a 308 and the risk of HCC. To determine this association, odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.Results: A total of 23 case-control studies were investigated, involving 3, 389 cases and 4, 235 controls. The overall conclusion was that the A allele was more frequent in case groups compared to control groups (13.4% vs.8.4%). Thus, the A allele was significantly associated with increased HCC risk (OR=1.77; 95% CI=[1.26-2.50]; P value<0.002). In addition to the allelic model, the dominant model (AA+AGvs. GG) was significantly associated with HCCrisk (OR=1.80; CI= [1.29-2.51]; P value<0.001). In the sensitivity analysis for co-dominant (AA vs. GG) and recessive models (AA vs. AG+GG), no trustworthy associations with the risk of HCC development were observed.Conclusions: This META-ANALYSIS indicated that the TNF-a 308 G/A polymorphism is significantly associated with increased susceptibility to HCC. However, to confirm this finding, more studies are needed on TNF-a 308 G/A POLYMORPHISMS associated with HCC.

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APA: Copy

TAVAKOLPOUR, SOHEIL, & SALI, SHAHNAZ. (2016). TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE). HEPATITIS MONTHLY, 16(4), 0-0. SID. https://sid.ir/paper/306992/en

Vancouver: Copy

TAVAKOLPOUR SOHEIL, SALI SHAHNAZ. TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE). HEPATITIS MONTHLY[Internet]. 2016;16(4):0-0. Available from: https://sid.ir/paper/306992/en

IEEE: Copy

SOHEIL TAVAKOLPOUR, and SHAHNAZ SALI, “TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE),” HEPATITIS MONTHLY, vol. 16, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306992/en

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