TREATMENT OF KAOLIN-INDUCED PAW EDEMA BY TRIFLUOPERAZINE IN THE RAT

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KHAKSARI M.; KHOUSHBATEN A.; HAJIZADEH S.

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Journal: DANESHVAR MEDICINE Year:2000 | Volume:7 | Issue:27 Page(s): 47-56

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Title

TREATMENT OF KAOLIN-INDUCED PAW EDEMA BY TRIFLUOPERAZINE IN THE RAT

Author(s)

KHAKSARI M. | KHOUSHBATEN A. | HAJIZADEH S. | Issue Writer Certificate

Keywords

TRIFLUPERAZINEQ3

KAOLINQ4

PAW EDEMAQ4

CALMODULINQ3

ACUTE INFLAMMATIONQ4

Abstract

, as a second messenger could play a role in activation of inflammatory cells. CALMODULIN is calcium binding protein and mediated many ca2+ -dependent processes in the cells. Trifluoperazine (TFP) is a CALMODULIN antagonist, and has antipsychotic action. In the present study we analyzed, the effect of TFP on KAOLIN - induced PAW EDEMA in rats and compared to anti-inflammatory effects of ibuprofen and bradykinin antagonist. The adult male rats were used. Acute inflammatory edema was induced by intraplantar injection of 0.1 ml of 2%, 4%, and 8% KAOLIN suspention for 1, 4, and 8 hours. Various doses of TFP (8, 32 mg/kg), ibuprofen (12 mg/kg), and B1 bradykinin receptor antagonist (0.1, and 0.5 mg/kg) given i.p. 15 min, before KAOLIN injection. PAW EDEMA assessed by calculation of a percentage of increase in Paw weight and by extravastion of Evans Blue dye in test Paws compared to the control paw. The results showed that KAOLIN at 4%, after 4 hours effectively inhanced paw weight by 183%, which was inhibited by TFP 98.8% and 93.9% at 8 and 32 mg/kg respectively. KAOLIN injection also induces 265.5% increase in Evans Blue extravasation, which was reduced by TFP (38%). No significant differences were found between inhibitory effects of TFP and ibuprofen on Evans Blue content, but, the inbibdory effect of TFP on paw weight was found to be more than ibuprofen (14.5 %). The anti -inflammatory effect of bradykinin antagonist was significantly lesser than other drugs. These data suggest that, CALMODULIN antagonist (TFP) effectively can inhibit KAOLIN -induced inflammatory edema, so that, these effects are comparable to ibuprofen, and more potent than Bl bradykinin receptor antagonist.

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APA: Copy

KHAKSARI, M., KHOUSHBATEN, A., & HAJIZADEH, S.. (2000). TREATMENT OF KAOLIN-INDUCED PAW EDEMA BY TRIFLUOPERAZINE IN THE RAT. DANESHVAR MEDICINE, 7(27), 47-56. SID. https://sid.ir/paper/30798/en

Vancouver: Copy

KHAKSARI M., KHOUSHBATEN A., HAJIZADEH S.. TREATMENT OF KAOLIN-INDUCED PAW EDEMA BY TRIFLUOPERAZINE IN THE RAT. DANESHVAR MEDICINE[Internet]. 2000;7(27):47-56. Available from: https://sid.ir/paper/30798/en

IEEE: Copy

M. KHAKSARI, A. KHOUSHBATEN, and S. HAJIZADEH, “TREATMENT OF KAOLIN-INDUCED PAW EDEMA BY TRIFLUOPERAZINE IN THE RAT,” DANESHVAR MEDICINE, vol. 7, no. 27, pp. 47–56, 2000, [Online]. Available: https://sid.ir/paper/30798/en

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