SURVEY OF DIFFERENT KINDS OF CLINICAL SIGNS, SYMPTOMS & LABARATORY ON 46 PATIENTS SUFFERING FROM WILSON DISEASE IN SHIRAZ

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IMANIEH M.H.; BARHAGH TALAB N.H.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2002 | Volume:9 | Issue:38 Page(s): 7-14

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Title

SURVEY OF DIFFERENT KINDS OF CLINICAL SIGNS, SYMPTOMS & LABARATORY ON 46 PATIENTS SUFFERING FROM WILSON DISEASE IN SHIRAZ

Author(s)

IMANIEH M.H. | BARHAGH TALAB N.H. | Issue Writer Certificate

Keywords

WILSON'S DISEASEQ4

FUMINANT HEPATITISQ4

KAISER FLEISHER RINGQ4

Abstract

Hepatolenticular degeneration (Wilson disease) is a hereditary disease in which Metabolic disorder of copper leads to the accumulation of Cu in the liver, brain, cornea and kidneys with consequent of pathologic changes in them. Hereditary mechanism of the disease is an autosomal recessive with prevalence of 1-100 per 1,000,000 inhabitants. This is a descriptive and retrospective study in which 46 patients suffering from wilson disease were diagnosed and studied during 3 years in Namazi Hospital, in Shiraz. The results show that 82% of patients had significant signs and symptoms and the average age was ±92.93 years (4-16). The most common symptom was abdominal protrusion (84.2%), 29(76%) had Jaundice, 28(74%) had As cites, 70% had KAISER FLEISHER RING. Abnormal abdominal examination was seen in 44 patients (45.5%) and abnormal Neurogical examination was seen in 19 patients (31.3%). Most of the patients had prolong PT, PTT, 32(70%) Hb<10 had. Normal U/A was seen in 17(36.5%) and most common abnormality, was hematuria in U/A. Abnormal LFT was seen in most patients. Fulminanat hepatitis was seen in 7 patients that all died from it. Our findings were similar to the other researches and dtudies. Finally we recommend the prevention of a new born child in family in which the child will born with wilson disease and also recommend that a child with jaundice (especially at age of 5-15 years old) suspection to wilson diseases is necessary. Siblings of the patients with wilson disease will be investigated to rule out wilson disease

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APA: Copy

IMANIEH, M.H., & BARHAGH TALAB, N.H.. (2002). SURVEY OF DIFFERENT KINDS OF CLINICAL SIGNS, SYMPTOMS & LABARATORY ON 46 PATIENTS SUFFERING FROM WILSON DISEASE IN SHIRAZ. DANESHVAR MEDICINE, 9(38), 7-14. SID. https://sid.ir/paper/30817/en

Vancouver: Copy

IMANIEH M.H., BARHAGH TALAB N.H.. SURVEY OF DIFFERENT KINDS OF CLINICAL SIGNS, SYMPTOMS & LABARATORY ON 46 PATIENTS SUFFERING FROM WILSON DISEASE IN SHIRAZ. DANESHVAR MEDICINE[Internet]. 2002;9(38):7-14. Available from: https://sid.ir/paper/30817/en

IEEE: Copy

M.H. IMANIEH, and N.H. BARHAGH TALAB, “SURVEY OF DIFFERENT KINDS OF CLINICAL SIGNS, SYMPTOMS & LABARATORY ON 46 PATIENTS SUFFERING FROM WILSON DISEASE IN SHIRAZ,” DANESHVAR MEDICINE, vol. 9, no. 38, pp. 7–14, 2002, [Online]. Available: https://sid.ir/paper/30817/en

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