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Information Journal Paper

Title

ELEVATED SERUM C-REACTIVE PROTEIN LEVEL AND MICROALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Pages

  12-16

Abstract

 Introduction: Microalbuminuria is a marker of vascular endothelial damage. In addition, it is reported that high serum levels of C-REACTIVE PROTEIN (CRP) is a novel cardiovascular risk factor that impairs endothelial function. The aim of this study was to evaluate the relationship between microalbuminuria and elevated serum level of high-sensitivity CRP (HS-CRP) in type 2 diabetic patients.Materials and Methods: We measured serum levels of HS-CRP in 87 patients with TYPE 2 DIABETES MELLITUS. They were divided into a microalbuminuric group (n=45) and those with a 24-hour urine albumin less than 30mg/d (n=42). The relationship of serum HS-CRP level with ALBUMINURIA and other characteristics of the patients were assessed.Results: Patients with microalbuminuria were significantly older and affected by diabetes mellitus longer than those without microalbuminuria. Also, their mean HS-CRP was significantly higher (4.98±1.45mg/L versus 2.82±2.10mg/L; P<.001). The Pearson correlation test showed a significant correlation between HS-CRP level and urine albumin level (r=0.43; P<.001). The specificity and sensitivity of HS-CRP for detection of microalbuminuria in were 78.5% and 68.8%, respectively, and the positive and negative predictive values were 77.5% and 70.2%, respectively.Conclusions: In type 2 diabetic patients, microalbuminuria is accompanied by elevated HS-CRP, suggesting activation of inflammatory pathways in progression of renal and cardiovascular atherosclerotic disease. As an easier and cheaper test for assessment of diabetic nephropathy, we recommend further studies on HS-CRP in diabetic patients.

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    APA: Copy

    MOJAHEDI, M.J., BONAKDARAN, SH., HAMI, M., SHEYKHIANI, M., SHAKERI, M.T., & AYAT ELAHI, HOSSEIN. (2009). ELEVATED SERUM C-REACTIVE PROTEIN LEVEL AND MICROALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 3(1), 12-16. SID. https://sid.ir/paper/308715/en

    Vancouver: Copy

    MOJAHEDI M.J., BONAKDARAN SH., HAMI M., SHEYKHIANI M., SHAKERI M.T., AYAT ELAHI HOSSEIN. ELEVATED SERUM C-REACTIVE PROTEIN LEVEL AND MICROALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2009;3(1):12-16. Available from: https://sid.ir/paper/308715/en

    IEEE: Copy

    M.J. MOJAHEDI, SH. BONAKDARAN, M. HAMI, M. SHEYKHIANI, M.T. SHAKERI, and HOSSEIN AYAT ELAHI, “ELEVATED SERUM C-REACTIVE PROTEIN LEVEL AND MICROALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 3, no. 1, pp. 12–16, 2009, [Online]. Available: https://sid.ir/paper/308715/en

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