LONG-TERM PROGRESSION PATTERN OF CHRONIC ALLOGRAFT DYSFUNCTION AMONG KIDNEY TRANSPLANT RECIPIENTS

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KHALKHALI H.R.; HAJIZADEH EBRAHIM; KAZEMNEJAD ANOUSHIRAVAN; GHAFARI ALI

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Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2010 | Volume:4 | Issue:3 Page(s): 244-249

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Information Journal Paper

Title

LONG-TERM PROGRESSION PATTERN OF CHRONIC ALLOGRAFT DYSFUNCTION AMONG KIDNEY TRANSPLANT RECIPIENTS

Author(s)

KHALKHALI H.R. | HAJIZADEH EBRAHIM | KAZEMNEJAD ANOUSHIRAVAN | GHAFARI ALI | Issue Writer Certificate

Keywords

KIDNEY TRANSPLANTATION

CHRONIC KIDNEY DYSFUNCTION

SURVIVAL ANALYSIS

Abstract

Introduction. There is little data about the pattern of disease progression in kidney transplant recipients with chronic allograft dysfunction (CAD). Extrapolating the current classification of chronic kidney disease for CAD, we studied the pattern of progression of CAD in 5 stages among our kidney transplant recipients.Materials and Methods. We performed a retrospective cohort study on 214 kidney transplant recipients with CAD. The selection criteria were a functioning kidney allograft for at least 1 year after transplantation and a progressive decline in allograft function. An event history analysis in survival data was carried out based on the stages of CAD at baseline and the end of the study. Results. At the beginning of the study, 54.7% of the patients had CAD stage 1; 37.9%, stage 2, and 7.5%, stage 3. At the end of study, 10.3% were in stage 2; 39.7%, stage 3; 23.4%, stage 4; and 26.6%, stage 5. Patients with CAD stage 5 were 17.1% of those in stage 1, 32.1% of those in stage 2, and 67.7% of those in stage 3 at baseline. There was a significant correlation between stage of CAD at the beginning of the study and the stage of CAD at the end (r = 0.465, P < .001).Conclusions. Because the decline in kidney allograft function was relatively faster in advanced stages of CAD, strategies to increase allograft survival by improving the baseline level of allograft function can be more effective than strategies to slow down progression of advanced stages of CAD.

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APA: Copy

KHALKHALI, H.R., HAJIZADEH, EBRAHIM, KAZEMNEJAD, ANOUSHIRAVAN, & GHAFARI, ALI. (2010). LONG-TERM PROGRESSION PATTERN OF CHRONIC ALLOGRAFT DYSFUNCTION AMONG KIDNEY TRANSPLANT RECIPIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 4(3), 244-249. SID. https://sid.ir/paper/309025/en

Vancouver: Copy

KHALKHALI H.R., HAJIZADEH EBRAHIM, KAZEMNEJAD ANOUSHIRAVAN, GHAFARI ALI. LONG-TERM PROGRESSION PATTERN OF CHRONIC ALLOGRAFT DYSFUNCTION AMONG KIDNEY TRANSPLANT RECIPIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2010;4(3):244-249. Available from: https://sid.ir/paper/309025/en

IEEE: Copy

H.R. KHALKHALI, EBRAHIM HAJIZADEH, ANOUSHIRAVAN KAZEMNEJAD, and ALI GHAFARI, “LONG-TERM PROGRESSION PATTERN OF CHRONIC ALLOGRAFT DYSFUNCTION AMONG KIDNEY TRANSPLANT RECIPIENTS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 4, no. 3, pp. 244–249, 2010, [Online]. Available: https://sid.ir/paper/309025/en

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