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Information Journal Paper

Title

INTERACTION OF SALVIGENIN WITH DNA

Pages

  69-76

Keywords

DNAQ3

Abstract

 Background and Objective: To evaluate INTERACTION of SALVIGENIN with DNA and the molecular mechanism of its anti-cancer effect.Materials and Methods: SALVIGENIN from Tanacetum canescens and DNA from calf thymus were isolated and purified. Then, SALVIGENIN INTERACTION with DNA in Tris buffer (0.05 M, pH equal to 4.7 and the temperature at 25 oC) was studied by different methods.Results and Conclusion: DNA absorption spectra in the presence of various concentrations of each of these ligands showed that the DNA with SALVIGENIN has INTERACTION and complex formation and the absorption wave length at 260 nm increased. Under the effect of changes in DNA uptake ligand showed structural changes. Also, using information obtained from the suppression with ethidium bromide of DNA complex by ligand skachard, above analysis indicated that the mechanism of suppression of publication is through non-competitive inhibition and it means that connecting mechanism of SALVIGENIN is non-intercalated with DNA and probably through connection small grooves.

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  • Cite

    APA: Copy

    HABIBI, ZOHREH, M. HASSAN, ZUHAIR, NOORI, SHOKOOFE, MOZAFARI, VALIOLAH, YOOSEFI, MARYAM, MOHAMMADI, MEHDI, & HASSANI, LILA. (2011). INTERACTION OF SALVIGENIN WITH DNA. DANESHVAR MEDICINE, 18(92), 69-76. SID. https://sid.ir/paper/30912/en

    Vancouver: Copy

    HABIBI ZOHREH, M. HASSAN ZUHAIR, NOORI SHOKOOFE, MOZAFARI VALIOLAH, YOOSEFI MARYAM, MOHAMMADI MEHDI, HASSANI LILA. INTERACTION OF SALVIGENIN WITH DNA. DANESHVAR MEDICINE[Internet]. 2011;18(92):69-76. Available from: https://sid.ir/paper/30912/en

    IEEE: Copy

    ZOHREH HABIBI, ZUHAIR M. HASSAN, SHOKOOFE NOORI, VALIOLAH MOZAFARI, MARYAM YOOSEFI, MEHDI MOHAMMADI, and LILA HASSANI, “INTERACTION OF SALVIGENIN WITH DNA,” DANESHVAR MEDICINE, vol. 18, no. 92, pp. 69–76, 2011, [Online]. Available: https://sid.ir/paper/30912/en

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