ATYPICAL HEMOLYTIC-UREMIC SYNDROME THE INTERPLAY BETWEEN COMPLEMENTS AND THE COAGULATION SYSTEM (REVIEW)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAYER ALI; ASIF ARIF

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2013 | Volume:7 | Issue:5 Page(s): 340-345

Download Full-Text

View:

369

Download:

123

Cites:

Information Journal Paper

Title

ATYPICAL HEMOLYTIC-UREMIC SYNDROME THE INTERPLAY BETWEEN COMPLEMENTS AND THE COAGULATION SYSTEM (REVIEW)

Author(s)

NAYER ALI | ASIF ARIF | Issue Writer Certificate

Keywords

ATYPICAL HEMOLYTICUREMIC SYNDROME

COMPLEMENT SYSTEM PROTEINS

BLOOD COAGULATION DISORDERS

Abstract

Hemolytic-uremic syndrome (HUS) is a rare life-threatening disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and impaired renal function. A thrombotic microangiopathy underlies the clinical features of HUS. In the majority of cases, HUS follows an infection with toxin-producing bacteria such as verotoxin-producing Escherichia coli. In some cases, HUS is not preceded by a clinically apparent infection, and therefore, is named atypical HUS. The prognosis of atypical HUS is poor. While mortality approaches 25% during the acute phase, endstage renal disease develops in nearly half of patients within a year. Evidence is accumulating that complement activation through the alternative pathway is at the heart of the pathophysiology leading to atypical HUS. Genetic abnormalities involving complement regulatory proteins and complement components form the molecular basis for complement activation. Since microvascular thrombosis is a quintessential feature of atypical HUS, complements and the coagulation system must work in tandem to give rise to the pathologic alterations observed in this condition. Here, a brief discussion of clinical and morphologic features of atypical HUS is followed by a concise presentation of the complement and coagulation systems. The interplay between complements and the coagulation system is graphically highlighted. Last but not least, conventional and emerging therapies for atypical HUS are outlined.

Cites

No record.

References

No record.

Cite

APA: Copy

NAYER, ALI, & ASIF, ARIF. (2013). ATYPICAL HEMOLYTIC-UREMIC SYNDROME THE INTERPLAY BETWEEN COMPLEMENTS AND THE COAGULATION SYSTEM (REVIEW). IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 7(5), 340-345. SID. https://sid.ir/paper/309442/en

Vancouver: Copy

NAYER ALI, ASIF ARIF. ATYPICAL HEMOLYTIC-UREMIC SYNDROME THE INTERPLAY BETWEEN COMPLEMENTS AND THE COAGULATION SYSTEM (REVIEW). IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2013;7(5):340-345. Available from: https://sid.ir/paper/309442/en

IEEE: Copy

ALI NAYER, and ARIF ASIF, “ATYPICAL HEMOLYTIC-UREMIC SYNDROME THE INTERPLAY BETWEEN COMPLEMENTS AND THE COAGULATION SYSTEM (REVIEW),” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 7, no. 5, pp. 340–345, 2013, [Online]. Available: https://sid.ir/paper/309442/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops