EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL

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MIRHASHEMI SEYYED MEHDI; RAHIMI FAEZEH; SOLEIMANI ALIREZA; ASEMI ZATOLLAH

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Journal Paper

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Journal: Iranian Journal of Kidney Diseases Year:2016 | Volume:10 | Issue:4 Page(s): 197-204

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Title

EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL

Author(s)

MIRHASHEMI SEYYED MEHDI | RAHIMI FAEZEH | SOLEIMANI ALIREZA | ASEMI ZATOLLAH | Issue Writer Certificate

Keywords

OMEGA-3 FATTY ACIDS

DIABETIC NEPHROPATHY

INFLAMMATORY MARKERS

ADVANCED GLYCATION END PRODUCTS

Abstract

Introduction.This study was performed to evaluate the effects of omega-3 fatty acid supplementation on inflammatory cytokines and ADVANCED GLYCATION END PRODUCTS (AGEs) in patients with DIABETIC NEPHROPATHY (DN).Materials and Methods.This randomized double-blind placebo controlled trial was done on 60 patients with DN who were randomly divided into 2 groups to receive either 1000 mg/d of omega-3 fatty acid from flaxseed oil (n=30) or placebo (n=30) for 12 weeks. The primary outcome variables were tumor necrosis factor-α, receptor tumor necrosis factor-α and growth differentiation factor 15. Fasting blood samples were taken at the onset and the end of the study to quantify the related markers.Results.Compared with the placebo, omega-3 fatty acid supplementation resulted in a significant decrease in serum AGEs (-2.3 ± 2.8 AU versus 0.2 ± 2.5 AU, P=.001). Despite a significant reduction in serum level of receptor for AGEs (-0.1 ± 0.3 AU, P=.02) in the omega-3 fatty acid group, no significant difference was found between the two groups in terms of their effects on the receptor for AGEs. Supplementation with omega-3 fatty acid had no significant effect on the inflammatory cytokines as compared with the placebo.Conclusions.Our study demonstrated that omega-3 fatty acid supplementation among DN patients had favorable effects on AGEs and the receptor for AGEs.

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APA: Copy

MIRHASHEMI, SEYYED MEHDI, RAHIMI, FAEZEH, SOLEIMANI, ALIREZA, & ASEMI, ZATOLLAH. (2016). EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 10(4), 197-204. SID. https://sid.ir/paper/309498/en

Vancouver: Copy

MIRHASHEMI SEYYED MEHDI, RAHIMI FAEZEH, SOLEIMANI ALIREZA, ASEMI ZATOLLAH. EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2016;10(4):197-204. Available from: https://sid.ir/paper/309498/en

IEEE: Copy

SEYYED MEHDI MIRHASHEMI, FAEZEH RAHIMI, ALIREZA SOLEIMANI, and ZATOLLAH ASEMI, “EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 10, no. 4, pp. 197–204, 2016, [Online]. Available: https://sid.ir/paper/309498/en

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