THE EVALUATION OF SICAM-1 AND CEA MOLECULES IN COLON CANCER PATIENTS BEFORE, AND AFTER OPERATION

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ANDALIB ALI REZA; HASHEMI NIA J.; GHASEMIAN SAFAEI H.; BABAZADEH SH.J.; OREZI F.; SAHEB FOSOUL F.; REZAEI A.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2006 | Volume:13 | Issue:62 Page(s): 51-56

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Title

THE EVALUATION OF SICAM-1 AND CEA MOLECULES IN COLON CANCER PATIENTS BEFORE, AND AFTER OPERATION

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Keywords

TUMOR MARKERQ3

LCAM-1Q2

CEAQ3

COLON CANCERQ3

Abstract

Introduction: Experimental studies show that some cancer cells including COLON CANCER cells up regulate the expression of Intracellular Adhesion Molecule-1 (ICAM-1, CD54). In addition, these protein molecules shed from the cell surfaces to the environments that could be detected in culture medium or patient serums. Carcino-embryonic antigen (CEA) has been known as a TUMOR MARKER, and is commercially available for detecting and following up the gut malignancy, specially the COLON CANCER. To determine and compare the serum levels of these molecules in COLON CANCER patients before and after operation, the present study has been designed.Materials & Methods: a group of patients (66% male and 34%femaleswith age ranges of 56±11 years) who were diagnosed for COLON CANCER pre- & post-operation in a University hospital was investigated. Their peripheral bloods were taken and their serums were isolated by standard and routine method. Similar procedure was performed for a healthy matched group, and then the serums for the molecule assessment were obtained using photometric enzyme immunoassay (or, ELISA).Results: The pre-operation levels of serum soluble molecule of patients were as follows: sICAM-1=781±219 ng/ml, and CEA=53.6±22.7 μg/l. In addition, the data obtained from healthy subjects showed the basal levels of sICAM-1=179±39 ng/ml, and CEA=3, 6±1.6 μg/l. However, after operation the mean±SD of samples indicated the following: sICAM-1=585±48 ng/ml, and CEA=41.3±26.5±g/l.Conclusion: CEA concentration as a TUMOR MARKER significantly increased in all the patients, moreover, sICAM-1 was augmented in the patient group four times more than the physiologic levels in healthy control group, the mean assessment of both molecules compared to decrease gradually after operation. Thus, it can be concluded that similar to CEA, sICAM1 can be considered as TUMOR MARKER to evaluate and follow up the situation in COLON CANCER.

Cites

EFFECT OF SPRINT TRAINING AND DETRAINING PERIOD ON CELLULAR ADHESION MOLECULE (SICAM-1) IN WISTAR RATS

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APA: Copy

ANDALIB, ALI REZA, HASHEMI NIA, J., GHASEMIAN SAFAEI, H., BABAZADEH, SH.J., OREZI, F., SAHEB FOSOUL, F., & REZAEI, A.. (2006). THE EVALUATION OF SICAM-1 AND CEA MOLECULES IN COLON CANCER PATIENTS BEFORE, AND AFTER OPERATION. DANESHVAR MEDICINE, 13(62), 51-56. SID. https://sid.ir/paper/30957/en

Vancouver: Copy

ANDALIB ALI REZA, HASHEMI NIA J., GHASEMIAN SAFAEI H., BABAZADEH SH.J., OREZI F., SAHEB FOSOUL F., REZAEI A.. THE EVALUATION OF SICAM-1 AND CEA MOLECULES IN COLON CANCER PATIENTS BEFORE, AND AFTER OPERATION. DANESHVAR MEDICINE[Internet]. 2006;13(62):51-56. Available from: https://sid.ir/paper/30957/en

IEEE: Copy

ALI REZA ANDALIB, J. HASHEMI NIA, H. GHASEMIAN SAFAEI, SH.J. BABAZADEH, F. OREZI, F. SAHEB FOSOUL, and A. REZAEI, “THE EVALUATION OF SICAM-1 AND CEA MOLECULES IN COLON CANCER PATIENTS BEFORE, AND AFTER OPERATION,” DANESHVAR MEDICINE, vol. 13, no. 62, pp. 51–56, 2006, [Online]. Available: https://sid.ir/paper/30957/en

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