EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE

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HONARVARAN F.; KESMATI M.; ESMAEILI M.H.; JAHANI HASHEMI H.; JAFARI H.; ABBASI E.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2007 | Volume:14 | Issue:69 Page(s): 27-32

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Title

EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE

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Keywords

ADDICTIONQ2

MORPHINEQ3

WITHDRAWAL SYNDROMEQ3

MATRICARIA CHAMOMILLAQ2

MICEQ2

Abstract

Background: Several studies show that MATRICARIA CHAMOMILLA extract can reduce pain, inflammation and anxiety. Therefore chronic administration of MATRICARIA CHAMOMILLA extract may be useful for MORPHINE WITHDRAWAL SYNDROME treatment Objective: To determine the effects of MATRICARIA CHAMOMILLA extract on MORPHINE WITHDRAWAL SYNDROME signs (MWS) in adult male MICE.Methods: 40 male MICE divided in 2 groups control (saline) and MORPHINE group. To develop MORPHINE dependence, MORPHINE group (n=8) was received MORPHINE (s.c) for 4 days. (10,20 and 40 mg/kg Three times in day for 3 days and 40 mg/kg MORPHINE in day 4) and divided in 4 sub groups. Three groups of them were received hydroalcholic extract of MATRICARIA CHAMOMILLA concurrently with each injection of MORPHINE (MC extract was administrated in 3 different dose 10, 20, and 30 mg/kg). one group of them was received MORPHINE only. Every MICE were received 5 mg/kg naloxone, 3h after last injection of MORPHINE in day 4 and then the frequencies of withdrawal behavior (jumping, climbing, rearing) and weight loss were assessed. Findings: Data analysis showed that co-administration of MATRICARIA CHAMOMILLA reduced withdrawal sings in low administrated dose. Conclusion: These results suggest that MATRICARIA CHAMOMILLA extract can attenuate withdrawal sings.

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APA: Copy

HONARVARAN, F., KESMATI, M., ESMAEILI, M.H., JAHANI HASHEMI, H., JAFARI, H., & ABBASI, E.. (2007). EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE. DANESHVAR MEDICINE, 14(69), 27-32. SID. https://sid.ir/paper/30965/en

Vancouver: Copy

HONARVARAN F., KESMATI M., ESMAEILI M.H., JAHANI HASHEMI H., JAFARI H., ABBASI E.. EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE. DANESHVAR MEDICINE[Internet]. 2007;14(69):27-32. Available from: https://sid.ir/paper/30965/en

IEEE: Copy

F. HONARVARAN, M. KESMATI, M.H. ESMAEILI, H. JAHANI HASHEMI, H. JAFARI, and E. ABBASI, “EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE,” DANESHVAR MEDICINE, vol. 14, no. 69, pp. 27–32, 2007, [Online]. Available: https://sid.ir/paper/30965/en

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