GASTRIC JUICE MICROORGANISM COLONIZATION FREQUENCY IN PATIENTS UNDER MECHANICAL VENTILATION IN TWO GROUPS OF RECEIVING RANITIDINE VS. SUCRALFATE

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MOJTAHEDZADEH M.; PANAHI Y.; ALIZADEH S.; NAGHIZADEH JAHROMI M.M.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2007 | Volume:14 | Issue:69 Page(s): 53-60

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Title

GASTRIC JUICE MICROORGANISM COLONIZATION FREQUENCY IN PATIENTS UNDER MECHANICAL VENTILATION IN TWO GROUPS OF RECEIVING RANITIDINE VS. SUCRALFATE

Author(s)

MOJTAHEDZADEH M. | PANAHI Y. | ALIZADEH S. | NAGHIZADEH JAHROMI M.M. | Issue Writer Certificate

Keywords

MICROBIAL COLONIZATIONQ3

RANITIDINEQ3

SUCRALFATEQ3

ASPIRATION PNEUMONIAQ3

Abstract

Objective: Acidic pH of stomach which is a normal physiological barrier against bacterial overgrowth would increase by stress ulcer prophylaxis initiation and may lead to bacterial colonization and develops a source for transition of infection to respiratory system and resulting in ventilator related pneumonia in patients admitted in Intensive Care Unite (ICU). Therefore finding methods to decrease the prevalence of ASPIRATION PNEUMONIA is an old debate. Currant survey has performed to evaluate effect of RANITIDINE and SUCRALFATE on bacterial colonization and developing ASPIRATION PNEUMONIA due to these drugs. Methods & Materials: It is a single blind randomized clinical trial in two groups of fifteen patients more than 20 years old admitted in ICU and under mechanical ventilation. One group had a regimen of one gram SUCRALFATE every 6 hrs by gavage and other had 50 mg of intravenous RANITIDINE every 8 hrs with a loading dose of 100 mg. There after we sampled gastric juice every 24 hrs for determining pH and pathogen type. Results: Gastric pH of RANITIDINE group was more than SUCRALFATE groups, both there were no significance. Common found microorganisms included pseudomonas, staphylococcus aureus, klebsiella, and candida albicans. ASPIRATION PNEUMONIA incidence rate was 16.7 percents (4 patients) in RANITIDINE group and 13.3 percents (2 patients) in SUCRALFATE group. Discussion: One of the causes of ASPIRATION PNEUMONIA in RANITIDINE consumers is higher gastric pH. Frequency of microorganisms was different in two groups (P=0.040) so that staphylococcus aureus and klebsiella were more in RANITIDINE group and pseudomonas and candida albicans were more in SUCRALFATE group.

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APA: Copy

MOJTAHEDZADEH, M., PANAHI, Y., ALIZADEH, S., & NAGHIZADEH JAHROMI, M.M.. (2007). GASTRIC JUICE MICROORGANISM COLONIZATION FREQUENCY IN PATIENTS UNDER MECHANICAL VENTILATION IN TWO GROUPS OF RECEIVING RANITIDINE VS. SUCRALFATE. DANESHVAR MEDICINE, 14(69), 53-60. SID. https://sid.ir/paper/30971/en

Vancouver: Copy

MOJTAHEDZADEH M., PANAHI Y., ALIZADEH S., NAGHIZADEH JAHROMI M.M.. GASTRIC JUICE MICROORGANISM COLONIZATION FREQUENCY IN PATIENTS UNDER MECHANICAL VENTILATION IN TWO GROUPS OF RECEIVING RANITIDINE VS. SUCRALFATE. DANESHVAR MEDICINE[Internet]. 2007;14(69):53-60. Available from: https://sid.ir/paper/30971/en

IEEE: Copy

M. MOJTAHEDZADEH, Y. PANAHI, S. ALIZADEH, and M.M. NAGHIZADEH JAHROMI, “GASTRIC JUICE MICROORGANISM COLONIZATION FREQUENCY IN PATIENTS UNDER MECHANICAL VENTILATION IN TWO GROUPS OF RECEIVING RANITIDINE VS. SUCRALFATE,” DANESHVAR MEDICINE, vol. 14, no. 69, pp. 53–60, 2007, [Online]. Available: https://sid.ir/paper/30971/en

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