مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

RECURRENT CORNEAL PERFORATION DUE TO CHRONIC GRAFT VERSUS HOST DISEASE, A CLINICOPATHOLOGIC REPORT (CASE REPORT)

Pages

  108-111

Abstract

 Purpose: To describe a case of chronic graft versus host disease (GVHD) leading to severe DRY EYE and recurrent CORNEAL PERFORATION in both eyes, its stepwise management and histopathological reports.Case Report: A 22-year-old woman with a history of thalassemia and subsequent high-dose chemotherapy followed by allogeneic bone marrow transplant (BMT) was referred to Farabi Eye Hospital. Despite aggressive medical and surgical intervention, corneal vascularization in her right eye progressed and led to CORNEAL PERFORATION. Cyanoacrylate glue was applied to seal the perforation, however it recurred. Multilayer amniotic membrane transplantation (AMT) was performed to seal the CORNEAL PERFORATION, which was effective for a short period. Subsequently, the CORNEAL PERFORATION recurred and penetrating keratoplasty was performed. After a few months deep vascularization and descemetocele occurred in the fellow left eye and the patient finally underwent therapeutic lamellar keratoplasty.Conclusion: Patients with GVHD are at risk of severe DRY EYE and subsequent corneal vascularization.Recurrent and recalcitrant CORNEAL PERFORATION resistant to cyanoacrylate glue and multilayer AMT may occur. Proper systemic and ocular management alongside close collaboration with the hematologist is strongly recommended to control the condition.

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  • Cite

    APA: Copy

    MOHAMMADPOUR, MEHRDAD, MALEKI, SIAMAK, HASHEMI, HASSAN, & BEHESHTNEJAD, AMIR HOUSHANG. (2016). RECURRENT CORNEAL PERFORATION DUE TO CHRONIC GRAFT VERSUS HOST DISEASE, A CLINICOPATHOLOGIC REPORT (CASE REPORT). JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 11(1), 108-111. SID. https://sid.ir/paper/311621/en

    Vancouver: Copy

    MOHAMMADPOUR MEHRDAD, MALEKI SIAMAK, HASHEMI HASSAN, BEHESHTNEJAD AMIR HOUSHANG. RECURRENT CORNEAL PERFORATION DUE TO CHRONIC GRAFT VERSUS HOST DISEASE, A CLINICOPATHOLOGIC REPORT (CASE REPORT). JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2016;11(1):108-111. Available from: https://sid.ir/paper/311621/en

    IEEE: Copy

    MEHRDAD MOHAMMADPOUR, SIAMAK MALEKI, HASSAN HASHEMI, and AMIR HOUSHANG BEHESHTNEJAD, “RECURRENT CORNEAL PERFORATION DUE TO CHRONIC GRAFT VERSUS HOST DISEASE, A CLINICOPATHOLOGIC REPORT (CASE REPORT),” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 11, no. 1, pp. 108–111, 2016, [Online]. Available: https://sid.ir/paper/311621/en

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