Real Life Outcomes vs. Clinical Trial Results (Perspective)

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ZARBIN MARCO

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ophthalmic and Vision Research Year:2019 | Volume:14 | Issue:1 Page(s): 88-92

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Information Journal Paper

Title

Real Life Outcomes vs. Clinical Trial Results (Perspective)

Author(s)

ZARBIN MARCO | Issue Writer Certificate

Keywords

Clinical Practice

Clinical Trial

Confidence Interval

P value

Rule of Three

Statistical Significance

Abstract

Two questions that clinicians should answer as they attempt to apply the results of Clinical Trials to Clinical Practice are: (1) will statistically significant results be reproduced in their Clinical Practice; and (2) if nothing goes wrong in a Clinical Trial, is everything alright? Regarding the first question, when considering the results of a randomized, multicenter, prospective, controlled Clinical Trial, two questions that cannot be addressed by simply by reading the trial results and that only the practicing clinician can answer are: (1) is the study population representative of the patient about to be treated; and (2) is the totality of evidence outside the trial (including the clinician’ s own extensive experience) consistent with the trial result? Regarding the second question, clinicians are advised to recognize that most studies, even Phase 3 trials, are underpowered to accurately assess the risk of low frequency events.

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APA: Copy

ZARBIN, MARCO. (2019). Real Life Outcomes vs. Clinical Trial Results (Perspective). JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 14(1), 88-92. SID. https://sid.ir/paper/311756/en

Vancouver: Copy

ZARBIN MARCO. Real Life Outcomes vs. Clinical Trial Results (Perspective). JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2019;14(1):88-92. Available from: https://sid.ir/paper/311756/en

IEEE: Copy

MARCO ZARBIN, “Real Life Outcomes vs. Clinical Trial Results (Perspective),” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 14, no. 1, pp. 88–92, 2019, [Online]. Available: https://sid.ir/paper/311756/en

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