MUSCARINIC AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS-MAZE ANXIETY TEST

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PIRI MORTEZA; NASEHI MOHAMMAD; HEIDARI NEGAR; SHAHIN M.A.S.; ZARRINDASTA M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DANESHVAR MEDICINE Year:2010 | Volume:18 | Issue:89 Page(s): 9-16

Download Full-Text

Persian Verion

View:

1,195

Download:

Cites:

Information Journal Paper

Title

MUSCARINIC AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS-MAZE ANXIETY TEST

Author(s)

Keywords

NMDA RECEPTORQ3

MUSCARINIC CHOLINERGIC RECEPTORQ3

DORSAL HIPPOCAMPUSQ2

ANXIETYQ2

RATQ2

Abstract

Background and Objective: Excitatory transmission through glutamate receptors is critical for cognition such as learning and ANXIETY. In the present study, the involvement of dorsal hippocampal MUSCARINIC CHOLINERGIC RECEPTOR on ANXIETY-like behavior induced by inhibition of NMDA RECEPTORs was investigated.Materials and Methods: In this experimental study, 105 adult male RATs weighing 200–250 g were used. The animals were anaesthetized and cannulae implanted bilaterally in the CA1 regions of the DORSAL HIPPOCAMPUS using stereotaxic device. Seven days after recovery from surgery, the behavioral testing was started in elevated plus maze task. The data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey test.Results: Our finding indicated that intra-CA1 administration of MK801 (2 mg/rat) and scopolamine (4 mg/rat) by itself increased percentage of open arm time and open arm entries but did not alter locomotion. On the other hand, intra- CA1 co-administration of ineffective doses of scopolamine with ineffective dose of MK801 (1 mg/rat) did not alter locomotion activity but increased percentage of open arm time and open arm entries.Conclusion: These results show that both NMDA RECEPTORs and MUSCARINIC CHOLINERGIC RECEPTORs not only play a part in the modulation of ANXIETY in the DORSAL HIPPOCAMPUS of RATs but also demonstrate a complex interaction as well.

Cites

No record.

References

No record.

Cite

Related Journal Papers