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Information Journal Paper

Title

ASSOCIATION BETWEEN GENETIC POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE WITH NON FAMILIAL COLORECTAL CANCER IN IRANIAN POPULATION

Pages

  131-136

Abstract

 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. One of the most important POLYMORPHISMs identified in the MTHFR gene is C677T. MTHFR activity is lowered in individuals with 677TT genotype.Using PYROSEQUENCING, we analyzed the MTHFR genotypes in 118 colorectal cancer patients and 189 normal matched controls. Whereas the CC, CT and TT genotypes of MTHFR among the colorectal cancer patients were 51.7%, 28.0 % and 20.3% respectively, we were able to find 47.1% of 677CC, 27.0% of 677CT and 25.9% of 677TT in normal controls. An inverse association was observed between the risk of colorectal cancer and TT genotype with the odds ratios (OR) of 1, 0.94 and 0.71 for CC, CT, and TT genotypes, respectively. This association was similar in both sexes, but in patients with high levels of folate intake. Our study corroborates previous findings of an inverse association between MTHFR 677TT genotype and colorectal cancer, especially at high levels of folate.

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    APA: Copy

    MONTAZER HAGHIGHI, M., RADPOUR, R., VAHEDI, MOHSEN, MOHEBI, S.R., KHATAMI, F., DERAKHSHAN, F., ATARIAN, H., & ZALI, MOHAMMAD REZA. (2008). ASSOCIATION BETWEEN GENETIC POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE WITH NON FAMILIAL COLORECTAL CANCER IN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 1(3), 131-136. SID. https://sid.ir/paper/312409/en

    Vancouver: Copy

    MONTAZER HAGHIGHI M., RADPOUR R., VAHEDI MOHSEN, MOHEBI S.R., KHATAMI F., DERAKHSHAN F., ATARIAN H., ZALI MOHAMMAD REZA. ASSOCIATION BETWEEN GENETIC POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE WITH NON FAMILIAL COLORECTAL CANCER IN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2008;1(3):131-136. Available from: https://sid.ir/paper/312409/en

    IEEE: Copy

    M. MONTAZER HAGHIGHI, R. RADPOUR, MOHSEN VAHEDI, S.R. MOHEBI, F. KHATAMI, F. DERAKHSHAN, H. ATARIAN, and MOHAMMAD REZA ZALI, “ASSOCIATION BETWEEN GENETIC POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE WITH NON FAMILIAL COLORECTAL CANCER IN IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 1, no. 3, pp. 131–136, 2008, [Online]. Available: https://sid.ir/paper/312409/en

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