HER2/NEU EXPRESSION IN WILMS' TUMOR AND CORRELATION WITH HISTOPATHOLOGIC FINDINGS

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BABASHAHI MASHAALLAH; MEHRAZMA MITRA; NASIRI SEYED JAVAD; AZIZI JALILIAN FARID; REZAEI TAVIRANI MOSTAFA

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Journal: INTERNATIONAL JOURNAL OF CANCER MANAGEMENT Year:2013 | Volume:6 | Issue:3 Page(s): 160-164

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Title

HER2/NEU EXPRESSION IN WILMS' TUMOR AND CORRELATION WITH HISTOPATHOLOGIC FINDINGS

Author(s)

Keywords

HER2/NEU

WILMS' TUMOR

NEPHROBLASTOMA

TUMOR COMPONENT

Abstract

Background: Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival.Methods: In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed.Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system.Results: Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components.Conclusion: This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.

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APA: Copy

BABASHAHI, MASHAALLAH, MEHRAZMA, MITRA, NASIRI, SEYED JAVAD, AZIZI JALILIAN, FARID, & REZAEI TAVIRANI, MOSTAFA. (2013). HER2/NEU EXPRESSION IN WILMS' TUMOR AND CORRELATION WITH HISTOPATHOLOGIC FINDINGS. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 6(3), 160-164. SID. https://sid.ir/paper/312592/en

Vancouver: Copy

BABASHAHI MASHAALLAH, MEHRAZMA MITRA, NASIRI SEYED JAVAD, AZIZI JALILIAN FARID, REZAEI TAVIRANI MOSTAFA. HER2/NEU EXPRESSION IN WILMS' TUMOR AND CORRELATION WITH HISTOPATHOLOGIC FINDINGS. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2013;6(3):160-164. Available from: https://sid.ir/paper/312592/en

IEEE: Copy

MASHAALLAH BABASHAHI, MITRA MEHRAZMA, SEYED JAVAD NASIRI, FARID AZIZI JALILIAN, and MOSTAFA REZAEI TAVIRANI, “HER2/NEU EXPRESSION IN WILMS' TUMOR AND CORRELATION WITH HISTOPATHOLOGIC FINDINGS,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 6, no. 3, pp. 160–164, 2013, [Online]. Available: https://sid.ir/paper/312592/en

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