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Information Journal Paper

Title

GENETIC PROFILE VARIATION IN VACCINE STRAINS AND CLINICAL ISOLATES OF BORDETELLA PERTUSSIS RECOVERED FROM IRANIAN PATIENTS

Pages

  178-184

Abstract

 Background: Re-emergence of pertussis has been reported in Iran despite a high rate of VACCINATION coverage. Low efficacy of the vaccine might be due to the genetic divergence between clinical versus vaccine strains. In the current study, the genetic profiles of clinical isolates and vaccine strains of BORDETELLA PERTUSSIS (B. pertussis) were assessed by using Pulsed Field Gel Electrophoresis (PFGE).Methods: Following phenotypic and molecular identification of isolates, XbaIdigested genomic DNA of 5 clinical isolates, 2 vaccine strains and a Tohama I strain were analyzed by PFGE along with B. parapertussis as a control.Results: Seven distinct PFGE PROFILEs were found among all examined isolates/ strains. In 5 clinical isolates, 4 profiles were identified whereas the vaccine strains displayed 2 distinct profiles. The reference strain, Tohama I had a distinct profile. Vaccine and clinical profiles had low similarity, with relatedness of approximately 40%.Conclusion: The genetic profiles of B. pertussis were different between circulating isolates and vaccine strains used in the national VACCINATION programs. Since new genetic profiles of B. pertussis can be disseminated periodically, the profiles of isolates circulating in the population should be monitored over the course of the re-emergence.

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    APA: Copy

    HAGHIGHI, FAEZEH, SHAHCHERAGHI, FERESHTEH, ABBASI, EBRAHIM, ESHRAGHI, SEYEDSAEED, ZERAATI, HOJJAT, MOUSAVI, SEYED ALI JAVAD, ASGARIAN OMRAN, HOSSEIN, DOURAGHI, MASOUMEH, & SHOKRI, FAZEL. (2014). GENETIC PROFILE VARIATION IN VACCINE STRAINS AND CLINICAL ISOLATES OF BORDETELLA PERTUSSIS RECOVERED FROM IRANIAN PATIENTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 6(3), 178-184. SID. https://sid.ir/paper/313841/en

    Vancouver: Copy

    HAGHIGHI FAEZEH, SHAHCHERAGHI FERESHTEH, ABBASI EBRAHIM, ESHRAGHI SEYEDSAEED, ZERAATI HOJJAT, MOUSAVI SEYED ALI JAVAD, ASGARIAN OMRAN HOSSEIN, DOURAGHI MASOUMEH, SHOKRI FAZEL. GENETIC PROFILE VARIATION IN VACCINE STRAINS AND CLINICAL ISOLATES OF BORDETELLA PERTUSSIS RECOVERED FROM IRANIAN PATIENTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2014;6(3):178-184. Available from: https://sid.ir/paper/313841/en

    IEEE: Copy

    FAEZEH HAGHIGHI, FERESHTEH SHAHCHERAGHI, EBRAHIM ABBASI, SEYEDSAEED ESHRAGHI, HOJJAT ZERAATI, SEYED ALI JAVAD MOUSAVI, HOSSEIN ASGARIAN OMRAN, MASOUMEH DOURAGHI, and FAZEL SHOKRI, “GENETIC PROFILE VARIATION IN VACCINE STRAINS AND CLINICAL ISOLATES OF BORDETELLA PERTUSSIS RECOVERED FROM IRANIAN PATIENTS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 6, no. 3, pp. 178–184, 2014, [Online]. Available: https://sid.ir/paper/313841/en

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