Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

482
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

185
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

NEW INSIGHTS INTO VEGF-A ALTERNATIVE SPLICING: KEY REGULATORY SWITCHING IN THE PATHOLOGICAL PROCESS

Pages

  192-199

Abstract

 Vascular endothelial growth factor (VEGF-A) is one of the most important regulatory factors in pathological and physiological angiogenesis. ALTERNATIVE SPLICING is a complicated molecular process in VEGF-A gene expression which adds complexity to VEGF-A biology. Among all VEGF-A exons, ALTERNATIVE SPLICING of exon 8 is the key determinant of isoform switching from pro-angiogenic VEGF-xxx to anti-angiogenic VEGF-xxxb. This is known as a key molecular switching in many pathological situations. In fact, the balance between VEGF-xxx and VEGF-xxxb isoforms is a critical controlling switch in both conditions of HEALTH and DISEASE. Here, the properties of VEGF-xxx and VEGFxxxb isoforms were discussed and their regulatory mechanism and their roles in certain pathological processes were evaluated. In summary, it was suggested that C-terminal VEGF-A ALTERNATIVE SPLICING can provide a new treatment opportunity in angiogenic DISEASEs.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    DEHGHANIAN, FARIBA, HOJATI, ZOHREH, & KAY, MARYAM. (2014). NEW INSIGHTS INTO VEGF-A ALTERNATIVE SPLICING: KEY REGULATORY SWITCHING IN THE PATHOLOGICAL PROCESS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 6(4), 192-199. SID. https://sid.ir/paper/313852/en

    Vancouver: Copy

    DEHGHANIAN FARIBA, HOJATI ZOHREH, KAY MARYAM. NEW INSIGHTS INTO VEGF-A ALTERNATIVE SPLICING: KEY REGULATORY SWITCHING IN THE PATHOLOGICAL PROCESS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2014;6(4):192-199. Available from: https://sid.ir/paper/313852/en

    IEEE: Copy

    FARIBA DEHGHANIAN, ZOHREH HOJATI, and MARYAM KAY, “NEW INSIGHTS INTO VEGF-A ALTERNATIVE SPLICING: KEY REGULATORY SWITCHING IN THE PATHOLOGICAL PROCESS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 6, no. 4, pp. 192–199, 2014, [Online]. Available: https://sid.ir/paper/313852/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top