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Information Journal Paper

Title

POLYMORPHISMS IN THE ESTROGEN RECEPTOR BETA GENE AND THE RISK OF UNEXPLAINED RECURRENT SPONTANEOUS ABORTION

Pages

  150-154

Abstract

 Background: Recurrent Spontaneous Abortion (RSA) is caused by multiple genetic and non-genetic factors. Around 50% of the RSA cases have no known etiology and are considered as Unexplained RSA (URSA). Estrogens, via binding to their receptors, play an important role in female reproduction. This study aimed to investigate whether single nucleotide polymorphisms (SNPs; +1082G/A, +1730G/A and rs1256030 C/T) in the ESTROGEN RECEPTOR beta (ESR2) gene are associated with susceptibility to URSA in a population of Iranian women.Methods: In this case-control study, the study groups consisted of 240 subjects with a history of URSA and 102 fertile women as controls. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were measured on day 2-3 of menstrual cycle. Two functional SNPs, +1082G/A (a silent mutation in exon 5) and +1730G/A (3' untranslated region of the exon 8),and one intron,rs1256030C/T, in the ESR2 gene were genotyped, using POLYMERASE CHAIN REACTION- RESTRICTION FRAGMENT LENGTH POLYMORPHISM (PCR-RFLP) analysis.Results: Serum levels of LH were significantly increased in URSA women. No significant differences in distribution of +1082G/A, +1730G/A and rs1256030C/T between URSA and control groups were observed.Conclusion: Our findings suggest that the studied SNPs on ESR2 gene may not be associated with URSA.

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    APA: Copy

    MAHDAVIPOUR, MARZIEH, ZAREI, SAEED, FATEMI, RAMINA, EDALATKHAH, HALEH, HEIDARI VALA, HAMED, JEDDI TEHRANI, MAHMOOD, & IDALI, FARAH. (2017). POLYMORPHISMS IN THE ESTROGEN RECEPTOR BETA GENE AND THE RISK OF UNEXPLAINED RECURRENT SPONTANEOUS ABORTION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(3), 150-154. SID. https://sid.ir/paper/313924/en

    Vancouver: Copy

    MAHDAVIPOUR MARZIEH, ZAREI SAEED, FATEMI RAMINA, EDALATKHAH HALEH, HEIDARI VALA HAMED, JEDDI TEHRANI MAHMOOD, IDALI FARAH. POLYMORPHISMS IN THE ESTROGEN RECEPTOR BETA GENE AND THE RISK OF UNEXPLAINED RECURRENT SPONTANEOUS ABORTION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(3):150-154. Available from: https://sid.ir/paper/313924/en

    IEEE: Copy

    MARZIEH MAHDAVIPOUR, SAEED ZAREI, RAMINA FATEMI, HALEH EDALATKHAH, HAMED HEIDARI VALA, MAHMOOD JEDDI TEHRANI, and FARAH IDALI, “POLYMORPHISMS IN THE ESTROGEN RECEPTOR BETA GENE AND THE RISK OF UNEXPLAINED RECURRENT SPONTANEOUS ABORTION,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 3, pp. 150–154, 2017, [Online]. Available: https://sid.ir/paper/313924/en

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