مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

335
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

358
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Antibody-Drug Conjugates: Possibilities and Challenges (Review Article)

Pages

  3-23

Abstract

 The design of Antibody Drug Conjugates (ADCs) as efficient targeting agents for tumor cell is still in its infancy for clinical applications. This approach incorporates the antibody specificity and cell killing activity of chemically conjugated cytotoxic agents. Antibody in ADC structure acts as a targeting agent and a nanoscale carrier to deliver a therapeutic dose of cytotoxic cargo into desired tumor cells. Early ADCs encountered major obstacles including, low blood residency time, low penetration capacity to tumor microenvironment, low payload potency, immunogenicity, unusual off-target toxicity, drug resistance, and the lack of stable linkage in blood circulation. Although extensive studies have been conducted to overcome these issues, the ADCs based therapies are still far from having high-efficient clinical outcomes. This review outlines the key characteristics of ADCs including tumor marker, antibody, cytotoxic payload, and linkage strategy with a focus on technical improvement and some future trends in the pipeline.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Nejadmoghaddam, Mohammad Reza, MINAEI TEHRANI, ARASH, GHAHREMANZADEH, RAMIN, MAHMOUDI, MORTEZA, & DINARVAND, RASSOUL. (2019). Antibody-Drug Conjugates: Possibilities and Challenges (Review Article). AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(1), 3-23. SID. https://sid.ir/paper/314013/en

    Vancouver: Copy

    Nejadmoghaddam Mohammad Reza, MINAEI TEHRANI ARASH, GHAHREMANZADEH RAMIN, MAHMOUDI MORTEZA, DINARVAND RASSOUL. Antibody-Drug Conjugates: Possibilities and Challenges (Review Article). AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(1):3-23. Available from: https://sid.ir/paper/314013/en

    IEEE: Copy

    Mohammad Reza Nejadmoghaddam, ARASH MINAEI TEHRANI, RAMIN GHAHREMANZADEH, MORTEZA MAHMOUDI, and RASSOUL DINARVAND, “Antibody-Drug Conjugates: Possibilities and Challenges (Review Article),” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 1, pp. 3–23, 2019, [Online]. Available: https://sid.ir/paper/314013/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button