A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq

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Chemmugil p.; PTV Lakshmi; ANNAMALAI A.

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Journal: Avicenna Journal of Medical Biotechnology Year:2019 | Volume:11 | Issue:1 Page(s): 48-58

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Title

A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq

Author(s)

Chemmugil p. | PTV Lakshmi | ANNAMALAI A. | Issue Writer Certificate

Keywords

Antibiotics

DNA binding domain

Methicillin resistant Staphylococcus aureus

Quorum sensing

Staphylococcus aureus

Abstract

Background: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to Antibiotics, hence, urging the need for alternative medicines. Methods: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatography was subjected to antibacterial and anti-Quorum sensing activity against S. aureus and Staphylococcus aureus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Methicillin resistant Staphylococcus aureus (MRSA). Results: The obtained results confirmed fraction F44 to have significant effect as antimicrobial and anti-biofilm agent against both the micro-organism. Therefore, few of such highly active fractions were chemical finger printed using GC-MS and the compounds identified were further docked with DNA binding (LytTR) domain of agrA, which revealed that compounds identified from fraction were interactive to the protein. Conclusion: R. patula is promising antimicrobial and anti-biofilm agent against S. aureus and MRSA.

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APA: Copy

Chemmugil, p., PTV, Lakshmi, & ANNAMALAI, A.. (2019). A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(1), 48-58. SID. https://sid.ir/paper/314014/en

Vancouver: Copy

Chemmugil p., PTV Lakshmi, ANNAMALAI A.. A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(1):48-58. Available from: https://sid.ir/paper/314014/en

IEEE: Copy

p. Chemmugil, Lakshmi PTV, and A. ANNAMALAI, “A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 1, pp. 48–58, 2019, [Online]. Available: https://sid.ir/paper/314014/en

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