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Information Journal Paper

Title

ASSOCIATION OF HHV-6 WITH HODGKIN AND NON HODGKIN LYMPHOMA

Pages

  153-158

Abstract

 Background and Objectives: Human Herpes 6 virus (HHV-6) could remain latent and chronic in the host cells after primary infection. HHV-6 genome encodes certain transactivation proteins which may results in development of malignant lymphoma. The association of human herpes six virus (HHV-6) infection and Hodgkin and NON-HODGKIN LYMPHOMAs is strongly supported by epidemiological studies. The aim of this study was to determine the prevalence of HHV-6 among the patients with Hodgkin, Non- Hodgkin`s lymphoma.Materials and Methods: Overall 44 blocks of formalin-fixed, paraffin-embedded of the patients including 22(50%) Hodgkin and 22(50%) NON-HODGKIN LYMPHOMA were collected. Initially the section of 5μm-thickness were prepared from the formalin-fixed, paraffin-embedded tissue blocks. Then the deparaphinazation was carried out for each sample. The DNA was extracted, followed by NESTED PCR for detection of HHV-6. Based on PCR product size and sequencing, the HHV-6 A or B subtypes were characterized.Results: 12.22 (54.54%) cases of Hodgkin and 8.22 (36.36%) Non-Hodgkin’s lymphoma were shown as positive for HHV-6. Out of 12 positive HHV-6 in HODGKIN LYMPHOMA, 10 patients (45.45%) belonged to variant A while 2 cases (9.09%) were found positive for both HHV-6A and HHV-6B. All the Non Hodgkin samples (n=8, 36.36%) showed positive for HHV-6 variant A.Conclusion: High prevalence of HHV-6 was found among the patients with Hodgkin and Non-Hodgkin’s lymphoma. Two patients with HODGKIN LYMPHOMA had mixed HHV-6A and HHV-6B infections. It is recommended patients with Hodgkin and Non-Hodgkin should be screened for HHV-6 detection before chemotherapy.

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    APA: Copy

    KIANI, HADIS, MAKVANDI, MANOOCHEHR, SAMARBAFZADEH, ALIREZA, TEIMOORI, ALI, NISI, NILOOFAR, MEHRAVARAN, HAMIDE, RADMEHR, HASHEM, HOSSEINI, ZEINAB, HAGHI, AZADEH, SHAHANI, TORAN, VARNASERI, MEHRAN, & RANJBARI, NASTARAN. (2016). ASSOCIATION OF HHV-6 WITH HODGKIN AND NON HODGKIN LYMPHOMA. IRANIAN JOURNAL OF MICROBIOLOGY, 8(2), 153-158. SID. https://sid.ir/paper/315373/en

    Vancouver: Copy

    KIANI HADIS, MAKVANDI MANOOCHEHR, SAMARBAFZADEH ALIREZA, TEIMOORI ALI, NISI NILOOFAR, MEHRAVARAN HAMIDE, RADMEHR HASHEM, HOSSEINI ZEINAB, HAGHI AZADEH, SHAHANI TORAN, VARNASERI MEHRAN, RANJBARI NASTARAN. ASSOCIATION OF HHV-6 WITH HODGKIN AND NON HODGKIN LYMPHOMA. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(2):153-158. Available from: https://sid.ir/paper/315373/en

    IEEE: Copy

    HADIS KIANI, MANOOCHEHR MAKVANDI, ALIREZA SAMARBAFZADEH, ALI TEIMOORI, NILOOFAR NISI, HAMIDE MEHRAVARAN, HASHEM RADMEHR, ZEINAB HOSSEINI, AZADEH HAGHI, TORAN SHAHANI, MEHRAN VARNASERI, and NASTARAN RANJBARI, “ASSOCIATION OF HHV-6 WITH HODGKIN AND NON HODGKIN LYMPHOMA,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 2, pp. 153–158, 2016, [Online]. Available: https://sid.ir/paper/315373/en

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