PREVALENCE OF HEPATITIS C VIRUS GENOTYPE 3A IN PATIENTS WITH HODGKIN AND NON-HODGKIN LYMPHOMA

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RADMEHR HASHEM; MAKVANDI MANOCHEHR; SAMARBAFZADEH ALIREZA; TEYMOURI ALI; NEISI NILOOFAR; RASTI MOJTABA; ABASIFAR SARA; SOLTANI HASAN; ABBASI SAMANEH; KIANI HADIS; MEHRAVARAN HAMIDE; AZARAN AZARAKHSH; SHAHANI TORAN

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Journal Paper

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Journal: Iranian Journal of Microbiology Year:2016 | Volume:8 | Issue:6 Page(s): 389-394

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Title

PREVALENCE OF HEPATITIS C VIRUS GENOTYPE 3A IN PATIENTS WITH HODGKIN AND NON-HODGKIN LYMPHOMA

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Keywords

NESTED RT-PCR

HEPATITIS C VIRUS

HODGKIN LYMPHOMA

NON-HODGKIN LYMPHOMA

GENOTYPE

Abstract

Background and Objectives: HEPATITIS C VIRUS (HCV) is a major public health problem worldwide. Replication and persistenceof HCV genome have been described in the liver tissue as well as B cells lymphocyte. Several investigations havereported that long-term persistence of HCV in B cells may result in Hodgkin and NON-HODGKIN LYMPHOMA. This studywas aimed to determine frequency of HCV RNA in histological tissues obtained from patients suffered from Hodgkin andNon-Hodgkin lymphoma.Materials and Methods: 52 formalin-fixed paraffin-embedded tissue blocks including 23 (44.3%) Hodgkin and 29 (55.7%)Non-Hodgkin samples were collected and five micrometer sections were prepared. RNA was extracted and cDNA was synthesized.Two consecutive NESTED RT-PCR assays were carried out for detection of HCV 5’ UTR and core gene. RT-PCRproducts were sequenced and aligned to construct HCV phylogenic tree to evaluate the homology of sequences in comparisonto the reference sequences retrieved from Genbank.Results: Overall, 6 Non-Hodgkin (20.6%) and 3 HODGKIN LYMPHOMA (13.04%) samples showed positive PCR results forboth 5’ UTR and HCV core RNA via nested PCR (P<0.469). Sequencing results revealed that all detected HCV RNA samplesbelonged to the GENOTYPE 3a.Conclusion: Despite low prevalence of HCV infection in Iran, high frequency of HCV RNA GENOTYPEs 3a (17.3%) has beenfound in patients with Hodgkin and NON-HODGKIN LYMPHOMA. To improve treatment regimens, screening of HCV RNA inpatients suffered from Hodgkin or NON-HODGKIN LYMPHOMA is recommended which can be done through highly sensitivemolecular means before and after immunosuppression status.

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APA: Copy

RADMEHR, HASHEM, MAKVANDI, MANOCHEHR, SAMARBAFZADEH, ALIREZA, TEYMOURI, ALI, NEISI, NILOOFAR, RASTI, MOJTABA, ABASIFAR, SARA, SOLTANI, HASAN, ABBASI, SAMANEH, KIANI, HADIS, MEHRAVARAN, HAMIDE, AZARAN, AZARAKHSH, & SHAHANI, TORAN. (2016). PREVALENCE OF HEPATITIS C VIRUS GENOTYPE 3A IN PATIENTS WITH HODGKIN AND NON-HODGKIN LYMPHOMA. IRANIAN JOURNAL OF MICROBIOLOGY, 8(6), 389-394. SID. https://sid.ir/paper/315440/en

Vancouver: Copy

RADMEHR HASHEM, MAKVANDI MANOCHEHR, SAMARBAFZADEH ALIREZA, TEYMOURI ALI, NEISI NILOOFAR, RASTI MOJTABA, ABASIFAR SARA, SOLTANI HASAN, ABBASI SAMANEH, KIANI HADIS, MEHRAVARAN HAMIDE, AZARAN AZARAKHSH, SHAHANI TORAN. PREVALENCE OF HEPATITIS C VIRUS GENOTYPE 3A IN PATIENTS WITH HODGKIN AND NON-HODGKIN LYMPHOMA. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(6):389-394. Available from: https://sid.ir/paper/315440/en

IEEE: Copy

HASHEM RADMEHR, MANOCHEHR MAKVANDI, ALIREZA SAMARBAFZADEH, ALI TEYMOURI, NILOOFAR NEISI, MOJTABA RASTI, SARA ABASIFAR, HASAN SOLTANI, SAMANEH ABBASI, HADIS KIANI, HAMIDE MEHRAVARAN, AZARAKHSH AZARAN, and TORAN SHAHANI, “PREVALENCE OF HEPATITIS C VIRUS GENOTYPE 3A IN PATIENTS WITH HODGKIN AND NON-HODGKIN LYMPHOMA,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 6, pp. 389–394, 2016, [Online]. Available: https://sid.ir/paper/315440/en

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