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Title

ISOLATION, MOLECULAR IDENTIFICATION, AND ANTIFUNGAL SUSCEPTIBILITY PROFILES OF VAGINAL ISOLATES OF CANDIDA SPECIES

Pages

  410-417

Abstract

 Background and Objectives: Vulvovaginal candidiasis is a common fungal infection among women during reproductiveages. Although, CANDIDA ALBICANS is accounted as the main etiologic agent of vaginitis, non-albicans species have arisenduring last years. Resistant to antifungal drugs especially, FLUCONAZOLE has been more reported by researchers from aroundthe World. The aims of this study were to determine the prevalence of vulvovaginal candidiasis among suspected patientswith vaginitis, the frequency of Candida species, and the susceptibility profiles of isolates to CASPOFUNGIN, FLUCONAZOLE andclotrimazole.Materials and Methods: One hundred and twenty suspected women with vaginitis were examined by specialist physicianand sampled using moisture swabs. Swabs were inoculated on CHROMagar Candida plates, incubated at 35ºC and detectedall isolated Candida species using morphological, microcopy and molecular methods. The antifungal susceptibility tests withCASPOFUNGIN, FLUCONAZOLE and CLOTRIMAZOLE were applied using microdilution and Resazurin dye methods against all isolatedyeasts.Results: The cultures were positive for 34 (28.3%) samples and three Candida species including; C. albicans (88.2%), C.glabrata (8.8%) and C. kefyr (2.9%). Our study shows that only one isolate of C. albicans was resistant to CASPOFUNGIN at theconcentration of 2 μg/ml after 24h incubation that increased to 2 isolates after 48h incubation. All isolates were sensitive tofluconazole at the MIC ranges of 1-0.25 μg/ml, while 88.2% of them were inhibited at 0.25 μg/mL of CLOTRIMAZOLE. Candidaalbicans remains the most common agent of fungal vaginitis.Conclusion: Although all of Candida isolates were susceptible to FLUCONAZOLE in vitro, it should be used with caution for empiricaltherapy due to more resistant rates in clinic. In addition, due to valuable sensitivity of all tested strains to CASPOFUNGIN, it potentially can be presented as the first line therapy for CANDIDA VAGINITIS.

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    APA: Copy

    REZAEI MATEHKOLAEI, ALI, SHAFIEI, SHOKOOFE, & ZAREI MAHMOUDABADI, ALI. (2016). ISOLATION, MOLECULAR IDENTIFICATION, AND ANTIFUNGAL SUSCEPTIBILITY PROFILES OF VAGINAL ISOLATES OF CANDIDA SPECIES. IRANIAN JOURNAL OF MICROBIOLOGY, 8(6), 410-417. SID. https://sid.ir/paper/315446/en

    Vancouver: Copy

    REZAEI MATEHKOLAEI ALI, SHAFIEI SHOKOOFE, ZAREI MAHMOUDABADI ALI. ISOLATION, MOLECULAR IDENTIFICATION, AND ANTIFUNGAL SUSCEPTIBILITY PROFILES OF VAGINAL ISOLATES OF CANDIDA SPECIES. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(6):410-417. Available from: https://sid.ir/paper/315446/en

    IEEE: Copy

    ALI REZAEI MATEHKOLAEI, SHOKOOFE SHAFIEI, and ALI ZAREI MAHMOUDABADI, “ISOLATION, MOLECULAR IDENTIFICATION, AND ANTIFUNGAL SUSCEPTIBILITY PROFILES OF VAGINAL ISOLATES OF CANDIDA SPECIES,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 6, pp. 410–417, 2016, [Online]. Available: https://sid.ir/paper/315446/en

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