مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

284
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

103
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

HAPTOGLOBIN GENOTYPIC DISTRIBUTION IN IRANIAN PATIENTS WITH CORONARY HEART DISEASE

Pages

  19-24

Abstract

 HAPTOGLOBIN is a plasma protein with hemoglobin binding capacity. HAPTOGLOBIN has important biological functions such as binding to free hemoglobin and removes it from the circulation, thus preventing iron loss and kidney damage during intravascular hemolysis, superior antioxidant capacity, protection against free radicals. Studies on the distribution of Hp show that the gene frequencies of Hp dependent on geographical and genetic family. In the other, several authors have showed the correlation between HP types and different diseases, such as inflammation, infection, CARDIOVASCULAR diseases and malignant tumors. Smoking, hypertention, diabetes mellitus and serum lipid concentrations are risk factors for developing CARDIOVASCULAR diseases. In addition, Hp polymorphism has been proposed as a risk factor for developing atherosclerotic vasculare disease. In this study, the association between HAPTOGLOBIN genotypic distribution and the incidence of CORONARY HEART DISEASE investigated. 50 Iranian patients with CORONARY HEART DISEASE were randomly selected. Genomic DNA extracted from peripheral blood leukocytes. In PCRs with primers A and B, amplification products of 1757 and 3481 bp were amplified from genomic DNA containing alleles Hp1 and Hp2, respectively. In the population studied, the distribution of HAPTOGLOBIN polymorphism was 36% (n=18) for the Hp1-1 type, 62% (n=31) for the HP1-2 type, and 2% (n=1) for the HP2-2 type. The trend in this study showing a lower frequency of 3-vessel disease and less severe coronary artery stenosis in patients with the HP1-1 phenotype than in patients with the HP1 - 2 phenotypes may be indicative of a protective effect of the HP1-1 phenotype against the development of atherosclerotic coronary artery disease.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    KAZEMI, BAHRAM, KHALKHAL, ENSIEH, & SHABANI, ASHRAF. (2011). HAPTOGLOBIN GENOTYPIC DISTRIBUTION IN IRANIAN PATIENTS WITH CORONARY HEART DISEASE. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), 2(4), 19-24. SID. https://sid.ir/paper/315792/en

    Vancouver: Copy

    KAZEMI BAHRAM, KHALKHAL ENSIEH, SHABANI ASHRAF. HAPTOGLOBIN GENOTYPIC DISTRIBUTION IN IRANIAN PATIENTS WITH CORONARY HEART DISEASE. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES)[Internet]. 2011;2(4):19-24. Available from: https://sid.ir/paper/315792/en

    IEEE: Copy

    BAHRAM KAZEMI, ENSIEH KHALKHAL, and ASHRAF SHABANI, “HAPTOGLOBIN GENOTYPIC DISTRIBUTION IN IRANIAN PATIENTS WITH CORONARY HEART DISEASE,” ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), vol. 2, no. 4, pp. 19–24, 2011, [Online]. Available: https://sid.ir/paper/315792/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button