LDL PARTICLE SIZE AND REACTIVE OXYGEN METABOLITES IN DYSLIPIDEMIC PATIENTS

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KOTANI KAZUHIKO; TSUZAKI KOKORO; TANIGUCHI NOBUYUKI; SAKANE NAOKI

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Journal Paper

Paper Information

Journal: International Journal of Preventive Medicine Year:2012 | Volume:3 | Issue:3 Page(s): 160-166

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Title

LDL PARTICLE SIZE AND REACTIVE OXYGEN METABOLITES IN DYSLIPIDEMIC PATIENTS

Author(s)

KOTANI KAZUHIKO | TSUZAKI KOKORO | TANIGUCHI NOBUYUKI | SAKANE NAOKI | Issue Writer Certificate

Keywords

D-ROMS TEST

HYPERLIPIDEMIA

MEAN LDL PARTICLE SIZE

OXIDATIVE STRESS

SMALL DENSE LDL

Abstract

Objectives: Small dense low-density lipoprotein (sdLDL) which has a small LDL particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. The diacron reactive oxygen metabolites (d-ROMs) test has recently been introduced as an OXIDATIVE STRESS-related marker in the clinic. The aim of the present study was to investigate the correlation between the MEAN LDL PARTICLE SIZE and the OXIDATIVE STRESS status as evaluated by the d-ROMs in dyslipidemic patients.Methods: The study included 278 dyslipidemic patients (121 male and 157 female, mean age, 60 years). Clinical data including the conventional atherosclerotic risk factors in addition to the MEAN LDL PARTICLE SIZE measured with the gel electrophoresis and the d-ROMs were collected.Results: Male patients had a significantly smaller MEAN LDL PARTICLE SIZE than females (262.2±7.5 [SD] ns. 264.3±6.7 A P<0.05), while female patients had a significantly higher d-ROMs level than males (318±68 ns. 350±72 U. Carr., P<0.01). A multiple regression analysis revealed that there was an independent, significant, and inverse correlation between the MEAN LDL PARTICLE SIZE and the d-ROMs (b=-.19, P<0.05).Conclusions: These findings of the co-existence of both markers suggest that sdLDL and OXIDATIVE STRESS can be cooperative in atherogenesis, possibly leading to the incidence of CVD, in dyslipidemic patients.

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APA: Copy

KOTANI, KAZUHIKO, TSUZAKI, KOKORO, TANIGUCHI, NOBUYUKI, & SAKANE, NAOKI. (2012). LDL PARTICLE SIZE AND REACTIVE OXYGEN METABOLITES IN DYSLIPIDEMIC PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 3(3), 160-166. SID. https://sid.ir/paper/316028/en

Vancouver: Copy

KOTANI KAZUHIKO, TSUZAKI KOKORO, TANIGUCHI NOBUYUKI, SAKANE NAOKI. LDL PARTICLE SIZE AND REACTIVE OXYGEN METABOLITES IN DYSLIPIDEMIC PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2012;3(3):160-166. Available from: https://sid.ir/paper/316028/en

IEEE: Copy

KAZUHIKO KOTANI, KOKORO TSUZAKI, NOBUYUKI TANIGUCHI, and NAOKI SAKANE, “LDL PARTICLE SIZE AND REACTIVE OXYGEN METABOLITES IN DYSLIPIDEMIC PATIENTS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 3, no. 3, pp. 160–166, 2012, [Online]. Available: https://sid.ir/paper/316028/en

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