مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE FIRST MACROLIDE-RESISTANT BORDETELLA PERTUSSIS STRAINS ISOLATED FROM IRANIAN PATIENTS

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  0-0

Abstract

 Background: Whooping cough was considered as one of the major causes of childhood morbidity and mortality worldwide. Resistant isolates of BORDETELLA PERTUSSIS to MACROLIDES in some countries have been recently reported.Objectives: Recent reports on macrolide-resistant B. pertussis isolates and lack of evidence for such resistance in clinical isolates of the Iranian patients led the authors of the current study to study antibiotic susceptibility of the collected isolates in the country. Susceptibility of the B. pertussis isolates to three antibiotics was studied. Relatedness of the strains recovered in this research was also examined.Materials and Methods: The antibacterial activities of erythromycin, azithromycin, and clarithromycin antibiotics against the recovered isolates of 779 nasopharyngeal swabs were examined using MIC (Minimum Inhibitory Concentration) method. Relationship of the strains was characterized by Pulsed-field Gel Electrophoresis (PFGE).Results: Among the specimens, 11 cases (1.4%) were culture-positive. Among these isolates, only two isolates had high MIC values for erythromycin and clarithromycin. Pulsed-field gel electrophoresis analysis of the isolates revealed 6 PFGE profiles (A-F) among which three and two isolates had the same patterns in profiles A and B, respectively.Conclusions: Azithromycin can be a good drug of choice to treat patients infected by B. pertussis in Iran. Clonal relationship of the isolates showed that the same B. pertussis strains were isolated from different patients in Iran.

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    APA: Copy

    SHAHCHERAGHI, FERESHTEH, NAKHOST LOTFI, MASOUMEH, NIKBIN, VAJIHEH SADAT, SHOORAJ, FAHIMEH, AZIZIAN, REZA, PARZADEH, MASOUMEH, ALLAHYAR TORKAMAN, MOHAMMAD REZA, & ZAHRAEI, SEYED MOHSEN. (2014). THE FIRST MACROLIDE-RESISTANT BORDETELLA PERTUSSIS STRAINS ISOLATED FROM IRANIAN PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(6), 0-0. SID. https://sid.ir/paper/317376/en

    Vancouver: Copy

    SHAHCHERAGHI FERESHTEH, NAKHOST LOTFI MASOUMEH, NIKBIN VAJIHEH SADAT, SHOORAJ FAHIMEH, AZIZIAN REZA, PARZADEH MASOUMEH, ALLAHYAR TORKAMAN MOHAMMAD REZA, ZAHRAEI SEYED MOHSEN. THE FIRST MACROLIDE-RESISTANT BORDETELLA PERTUSSIS STRAINS ISOLATED FROM IRANIAN PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(6):0-0. Available from: https://sid.ir/paper/317376/en

    IEEE: Copy

    FERESHTEH SHAHCHERAGHI, MASOUMEH NAKHOST LOTFI, VAJIHEH SADAT NIKBIN, FAHIMEH SHOORAJ, REZA AZIZIAN, MASOUMEH PARZADEH, MOHAMMAD REZA ALLAHYAR TORKAMAN, and SEYED MOHSEN ZAHRAEI, “THE FIRST MACROLIDE-RESISTANT BORDETELLA PERTUSSIS STRAINS ISOLATED FROM IRANIAN PATIENTS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 6, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/317376/en

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