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Information Journal Paper

Title

TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND GENE POLYMORPHISMS AND HEPATITIS B VIRUS INFECTION

Pages

  1-6

Abstract

 Background: TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) is an apoptotic molecule with a key role in the apoptosis of tumors and virus-infected cells. The association of 1525G/A and 1595C/T POLYMORPHISMs in the region of 3’ UTR on the TRAIL gene has been shown in many cancers and diseases. POLYMORPHISM at the positions of 1525G/A and 1595C/T might influence the clearance of HEPATITIS B VIRUS (HBV).Objectives: This study was carried out to determine the role of the TRAIL gene POLYMORPHISMs in clinical outcome of HBV infection.Patients and Methods: Polymerase chain reaction-based restriction fragment length POLYMORPHISM (PCR–RFLP) was applied to genotype TRAIL POLYMORPHISMs at positions 1525G/A and 1595C/T. To evaluate the TRAIL gene POLYMORPHISM in the 3’ UTR region at position 1525G/A and 1595C/T, 147 patients with HBV infection were divided into three different groups of chronic hepatitis (n=52), cirrhosis (n=33), and carrier (n=62) and there was a group of 101 healthy controls.Results: Our data showed that genotypes 1525G/A and 1595C/T were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. No significant differences in frequencies of genotype and alleles at positions 1525G/A and 1595C/T were observed between all the three groups (P value>0.05).Conclusions: According to our result, 1525G/A and 1595C/T were in strong linkage disequilibrium and the POLYMORPHISMs of the TRAIL gene in the 3’ UTR region were not associated with the outcome of HBV infection.

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    APA: Copy

    SOLEIMANI, ANVAR, RAFATPANAH, HOUSHANG, NIKPOOR, AMIN REZA, KARGARI, MEHRDAD, & HAMIDI ALAMDARI, DARYOUSH. (2015). TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND GENE POLYMORPHISMS AND HEPATITIS B VIRUS INFECTION. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(11), 1-6. SID. https://sid.ir/paper/317447/en

    Vancouver: Copy

    SOLEIMANI ANVAR, RAFATPANAH HOUSHANG, NIKPOOR AMIN REZA, KARGARI MEHRDAD, HAMIDI ALAMDARI DARYOUSH. TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND GENE POLYMORPHISMS AND HEPATITIS B VIRUS INFECTION. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(11):1-6. Available from: https://sid.ir/paper/317447/en

    IEEE: Copy

    ANVAR SOLEIMANI, HOUSHANG RAFATPANAH, AMIN REZA NIKPOOR, MEHRDAD KARGARI, and DARYOUSH HAMIDI ALAMDARI, “TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND GENE POLYMORPHISMS AND HEPATITIS B VIRUS INFECTION,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 11, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/317447/en

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