مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PREVALENCE AND CLONAL DISSEMINATION OF METALLO-BETA-LACTAMASE-PRODUCING PSEUDOMONAS AERUGINOSA IN KERMANSHAH

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  0-0

Abstract

 Background: PSEUDOMONAS AERUGINOSA is an opportunistic pathogen associated with nosocomial infections. The emergence and dissemination of METALLO-BETA-LACTAMASEs (MBLs) has contributed to the high rate of resistance among P. aeruginosa isolates.Objectives: The purpose of this study was to describe the prevalence and the CLONAL DISSEMINATION of MBL- producing P. aeruginosa isolates collected from major hospitals in Kermanshah.Materials and Methods: Antibiotic susceptibility testing was performed using the minimal inhibitory concentrations. The MBLs were investigated using the Double-Disk Synergy Test (DDST) and Polymerase Chain Reaction. MOLECULAR TYPING was performed by Pulsed-Field Gel Electrophoresis (PFGE).Results: Of the 60 P. aeruginosa isolates included in this study, 30 (50%) were resistant to Gentamicin, 38 (63.3%) to Piperacillin, 42 (70%) to Ceftazidime, and 45 (75%) to Cefepime. Twenty-nine (48.3%) isolates were MBL producers in the DDST test. Five (8.3%) isolates were positive for the VIM gene. PFGE analysis among the MBL producers revealed 12 distinct clonal patterns.Conclusions: The inter- and intra-hospital dissemination of resistant clones is a matter of concern and is an indicator of the level of the improvement and surveillance of standard hygiene, particularly disinfection and hand washing before and after contact with patients. Given the emergence of MBL-producing strains, surveillance has become an important procedure to control the transmission of resistant strains.

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References

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APA: Copy

AKYA, ALISHA, SALIMI, AFSANEH, NOMANPOUR, BIZHAN, & AHMADI, KAMAL. (2015). PREVALENCE AND CLONAL DISSEMINATION OF METALLO-BETA-LACTAMASE-PRODUCING PSEUDOMONAS AERUGINOSA IN KERMANSHAH. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(7), 0-0. SID. https://sid.ir/paper/317516/en

Vancouver: Copy

AKYA ALISHA, SALIMI AFSANEH, NOMANPOUR BIZHAN, AHMADI KAMAL. PREVALENCE AND CLONAL DISSEMINATION OF METALLO-BETA-LACTAMASE-PRODUCING PSEUDOMONAS AERUGINOSA IN KERMANSHAH. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(7):0-0. Available from: https://sid.ir/paper/317516/en

IEEE: Copy

ALISHA AKYA, AFSANEH SALIMI, BIZHAN NOMANPOUR, and KAMAL AHMADI, “PREVALENCE AND CLONAL DISSEMINATION OF METALLO-BETA-LACTAMASE-PRODUCING PSEUDOMONAS AERUGINOSA IN KERMANSHAH,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 7, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/317516/en

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