Role of Toll-Like Receptors in Tuberculosis Infection

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Biyikli Oguz Oben; Baysak Aysegul; Ece Gulfem; Oz Adnan Tolga; Ozhan Mustafa Hikmet; BERDELI AFIG

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Journal Paper

Paper Information

Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:10 Page(s): 0-0

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Title

Role of Toll-Like Receptors in Tuberculosis Infection

Author(s)

Keywords

Toll-Like Receptor

Infection

Genetic Polymorphism

Mycobacterium tuberculosis

Abstract

Background: One-third of the world’ s population is infected with Mycobacterium tuberculosis. Investigation of Toll-Like Receptors (TLRs) has revealed new information regarding the immunopathogenesis of this disease. Toll-Like Receptors can recognize various ligands with a lipoprotein structure in the bacilli. Toll-Like Receptor 2 and TLR-4 have been identified in association with tuberculosis Infection. Objectives: The aim of our study was to investigate the relationship between TLR polymorphism and Infection progress. Methods: Twenty-nine patients with a radiologically, microbiologically, and clinically proven active tuberculosis diagnosis were included in this 25-month study. Toll-Like Receptor 2 and TLR-4 polymorphisms and allele distributions were compared between these 29 patients and 100 healthy control subjects. Peripheral blood samples were taken from all patients. Genotyping of TLR-2, TLR-4, and macrophage migration inhibitory factor was performed. The extraction step was completed with a Qiagen mini blood purification system kit (Qiagen, Ontario, Canada) using a peripheral blood sample. The genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. Results: In total, 19 of the 29 patients with tuberculosis Infection had a TLR-2 polymorphism, and 20 of the 100 healthy subjects had a TLR-2 polymorphism (P < 0. 001). The TLR-4 polymorphism and interferon- allele distributions were not statistically correlated. Conclusions: Toll-Like Receptor 2 polymorphism is a risk factor for tuberculosis Infection. The limiting factor in this study was the lack of investigation of the interferon- and tumor necrosis factor- levels, which are important in the development of Infection. Detection of lower levels of these cytokines in bronchoalveolar lavage specimens, especially among patients with TLR-2 defects, will provide new data that may support the results of this study.

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APA: Copy

Biyikli, Oguz Oben, Baysak, Aysegul, Ece, Gulfem, Oz, Adnan Tolga, Ozhan, Mustafa Hikmet, & BERDELI, AFIG. (2016). Role of Toll-Like Receptors in Tuberculosis Infection. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(10), 0-0. SID. https://sid.ir/paper/317776/en

Vancouver: Copy

Biyikli Oguz Oben, Baysak Aysegul, Ece Gulfem, Oz Adnan Tolga, Ozhan Mustafa Hikmet, BERDELI AFIG. Role of Toll-Like Receptors in Tuberculosis Infection. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(10):0-0. Available from: https://sid.ir/paper/317776/en

IEEE: Copy

Oguz Oben Biyikli, Aysegul Baysak, Gulfem Ece, Adnan Tolga Oz, Mustafa Hikmet Ozhan, and AFIG BERDELI, “Role of Toll-Like Receptors in Tuberculosis Infection,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317776/en

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