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Information Journal Paper

Title

MEMORY-IMPROVING ACTIVITY OF MELISSA OFFICINALIS EXTRACT IN NAÏVE AND SCOPOLAMINE-TREATED RATS

Pages

  107-114

Abstract

 MELISSA OFFICINALIS L. (Labiatae) traditionally used in treating neurological disorders has also been identified as a MEMORY-enhancing herb. The extract of M. officinalis has a cholinergic property. The role of basal forebrain cholinergic neurons, the neurons that are destroyed in Alzheimer's disease (AD), in learning and MEMORY, is also well known. The aim of this study is to investigate the role of cholinergic system on the MEMORY improving activity of M. officinalis extract. The leaves of M. officinalis were extracted with ethanol 80% using the maceration method. Rats received intra-peritoneal injections of M. officinalis extract in different doses (50–400 mg/kg) alone or in combination with SCOPOLAMINE (1 mg/kg) before being trained in a Morris WATER MAZE (MWM) in a single-day training protocol. After training, the acetylcholinesterase enzyme (AChE) activity was measured in the hippocampus. Administration of M. officinalis extract (200 mg/kg) could significantly enhance learning and MEMORY of naive rats (p<0.001) and significantly ameliorate SCOPOLAMINE-induced learning deficit, but the effect of the extract was not dose dependent, and doses above 200 mg/kg could neither enhance MEMORY in naive rats nor reverse SCOPOLAMINE-induced MEMORY impairment. Also, inhibition of AChE activity was observed in both naive and SCOPOLAMINE-induced MEMORY-impaired rats. These results suggest that M. officinalis can improve MEMORY and that the cholinergic property of the extract may contribute to the MEMORY-improving effects observed in this study. Then M. officinalis extract has potential therapeutic value in alleviating certain MEMORY impairment observed in AD.

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    • Cite

    APA: Copy

    SOODI, M., NAGHDI, N., HAJIMEHDIPOOR, H., CHOOPANI, S., & SAHRAEI, E.. (2014). MEMORY-IMPROVING ACTIVITY OF MELISSA OFFICINALIS EXTRACT IN NAÏVE AND SCOPOLAMINE-TREATED RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(2), 107-114. SID. https://sid.ir/paper/318322/en

    Vancouver: Copy

    SOODI M., NAGHDI N., HAJIMEHDIPOOR H., CHOOPANI S., SAHRAEI E.. MEMORY-IMPROVING ACTIVITY OF MELISSA OFFICINALIS EXTRACT IN NAÏVE AND SCOPOLAMINE-TREATED RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2014;9(2):107-114. Available from: https://sid.ir/paper/318322/en

    IEEE: Copy

    M. SOODI, N. NAGHDI, H. HAJIMEHDIPOOR, S. CHOOPANI, and E. SAHRAEI, “MEMORY-IMPROVING ACTIVITY OF MELISSA OFFICINALIS EXTRACT IN NAÏVE AND SCOPOLAMINE-TREATED RATS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 9, no. 2, pp. 107–114, 2014, [Online]. Available: https://sid.ir/paper/318322/en

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