مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE

Pages

  109-115

Abstract

 BACKGROUND: There is no convenient cheap pragmatic EXPERIMENTAL MODEL for NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) /Nonalcoholic Steatohepatitis (NASH). Objective: Our objective was to create a pragmatic model of NAFLD/NASH.METHODS: Sprague-Dawley RATs were fed a high-fat, high sugar homemade DIET ad libitum for seven weeks. The high-fat, high sugar DIET included 59% of energy derived from fat, 30% from carbohydrates, and 11% from protein. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin, and hepatic tumor necrosis factor-alpha (TNF-a) gene expression were determined. Hepatic histology was examined by H & E stain.RESULTS: RATs fed the high-fat, high sugar DIET developed hepatic steatosis, and a moderate inflammation, which was associated with increased serum levels of liver enzymes, glucose, insulin, triglyceride, cholesterol, and hepatic TNF-a gene expression.CONCLUSION: This RAT model resembles the key features of human NAFLD/NASH and provides a simple pragmatic EXPERIMENTAL MODEL for elucidating the disease prevention and treatment.

Cites

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    • Cite

    APA: Copy

    EMAMAT, HADI, NOORI, MARYAM, FOROUGHI, FOROUGH, RISMANCHI, MARJAN, EINI ZINAB, HASSAN, & HEKMATDOOST, AZITA. (2016). AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(2), 109-115. SID. https://sid.ir/paper/319127/en

    Vancouver: Copy

    EMAMAT HADI, NOORI MARYAM, FOROUGHI FOROUGH, RISMANCHI MARJAN, EINI ZINAB HASSAN, HEKMATDOOST AZITA. AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2016;8(2):109-115. Available from: https://sid.ir/paper/319127/en

    IEEE: Copy

    HADI EMAMAT, MARYAM NOORI, FOROUGH FOROUGHI, MARJAN RISMANCHI, HASSAN EINI ZINAB, and AZITA HEKMATDOOST, “AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 8, no. 2, pp. 109–115, 2016, [Online]. Available: https://sid.ir/paper/319127/en

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