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Information Journal Paper

Title

INVESTIGATION OF PROGRAMMED CELL DEATH-1 (PD-1) GENE VARIATIONS AT POSITIONS PD1.3 AND PD1.5 IN IRANIAN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Pages

  13-17

Keywords

SINGLE NUCLEOTIDE POLYMORPHISMS (SNP) 

Abstract

 Background: Tumor cells express PD-1 ligands to bind PD-1 on immune cells and escape immune responses. In the present study, we aimed to investigate whether single nucleotide polymorphisms at positions PD1.3 (+7146, rs11568821) G/A, and PD1.5 (+7785 C/T, rs2227981) may be considered risk factors for susceptibility to nonsmall cell lung cancer in the Iranian population.Methods: This study enrolled 206 histopathologically confirmed lung cancer patients and 173 age/sex matched healthy controls. We performed PCR-RFLP to determine the genotypes of the extracted genomic DNA.Results: The frequencies of PD1.3 GG, GA and AA genotypes were 171 (83%), 31 (15%) and 4 (1.9%) out of 206 patients, and 144 (83.2%), 26 (15%), and 3 (1.7%) out of 173 controls, respectively. The frequencies of PD1.5 CC, CT and TT genotypes were 78 (37.9%), 100 (48.5%), and 28 (13.6%) in patients, and 60 (34.7%), 89 (51.4%), and 24 (13.9%) in controls. There were no significant differences in genotype analysis between patients and controls at positions PD1.3 (P=0.98) or PD1.5 (P=0.80). No significant differences existed in the frequencies of alleles and haplotypes between the two groups (P>0.05).Conclusion: Our data have indicated no association between PD1.3 (+7146) G/A and PD1.5 (+7785) C/T with susceptibility to non-small cell lung cancer. Investigation of other PD1 genetic variations and emerged haplotypes are required to completely define the role of PD1 genetic variations in susceptibility to lung cancer.

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    APA: Copy

    PIRDELKHOSH, ZAHRA, KAZEMI, TOHID, HAGHSHENAS, MOHAMMAD REZA, GHAYUMI, MOHAMMAD ALI, & ERFANI, NASROLLAH. (2018). INVESTIGATION OF PROGRAMMED CELL DEATH-1 (PD-1) GENE VARIATIONS AT POSITIONS PD1.3 AND PD1.5 IN IRANIAN PATIENTS WITH NON-SMALL CELL LUNG CANCER. MIDDLE EAST JOURNAL OF CANCER, 9(1), 13-17. SID. https://sid.ir/paper/321198/en

    Vancouver: Copy

    PIRDELKHOSH ZAHRA, KAZEMI TOHID, HAGHSHENAS MOHAMMAD REZA, GHAYUMI MOHAMMAD ALI, ERFANI NASROLLAH. INVESTIGATION OF PROGRAMMED CELL DEATH-1 (PD-1) GENE VARIATIONS AT POSITIONS PD1.3 AND PD1.5 IN IRANIAN PATIENTS WITH NON-SMALL CELL LUNG CANCER. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(1):13-17. Available from: https://sid.ir/paper/321198/en

    IEEE: Copy

    ZAHRA PIRDELKHOSH, TOHID KAZEMI, MOHAMMAD REZA HAGHSHENAS, MOHAMMAD ALI GHAYUMI, and NASROLLAH ERFANI, “INVESTIGATION OF PROGRAMMED CELL DEATH-1 (PD-1) GENE VARIATIONS AT POSITIONS PD1.3 AND PD1.5 IN IRANIAN PATIENTS WITH NON-SMALL CELL LUNG CANCER,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 1, pp. 13–17, 2018, [Online]. Available: https://sid.ir/paper/321198/en

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