مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Circulating miRNA-30a and miRNA-221 as Novel Biomarkers for the Early Detection of Non-Small-Cell Lung Cancer

Pages

  50-58

Abstract

 Background: Detecting non-small-cell Lung cancer at an early stage has become a great challenge due to the lack of a specific non-invasive marker. MicroRNAs are small, non-coding RNA molecules that play a role in carcinogenesis and cancer progression, as indicated by their abnormal expression in the patients’ plasma. Herein, we investigated the plasma level of circulating miRNA-30a and miRNA-221 as non-invasive markers for an early detection of non-small-cell Lung cancer. Method: A cross-sectional study was conducted at Assiut University Hospital, Egypt, to investigate miRNA-30a and miRNA-221 expression via quantitative real-time PCR in the plasma of patients with non-small-cell Lung cancer (n=70) and healthy controls (n=34). Receiver operating curves were used to evaluate the diagnostic value of miRNA-221 and miRNA-30a in non-small-cell Lung cancer. The relationship between both markers and patient clinical parameters was further assessed. Result: Circulating plasma miRNA-30a and miRNA-221 levels were significantly higher in the non-small-cell Lung cancer patients compared with those in the healthy controls (P<0. 05). There was a significant difference regarding the plasma miRNA-30a level among the three groups (the highest levels were recorded in adenocarcinoma, followed by large cell carcinoma and squamous cell carcinoma). ROC curve analysis of miRNA-30a and miRNA-221 showed that specificity and sensitivity were 60% and 80%, and 40% and 75%, respectively. Conclusion: miRNA-30a and miRNA-221 may be non-invasive Biomarkers for early detection and screening or therapeutic targets in patients with NSCLC. Future studies are warranted regarding the use of Biomarkers as therapeutic targets.

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    APA: Copy

    Abdel Ghany, Soad M., Ali, Esraa MA., Ahmed, Amr E., Hozayen, Walaa G., Mohamed Hussein, Aliae A.R., Elnaggar, Maha Salah, & Hetta, Helal F.. (2020). Circulating miRNA-30a and miRNA-221 as Novel Biomarkers for the Early Detection of Non-Small-Cell Lung Cancer. MIDDLE EAST JOURNAL OF CANCER, 11(1), 50-58. SID. https://sid.ir/paper/321317/en

    Vancouver: Copy

    Abdel Ghany Soad M., Ali Esraa MA., Ahmed Amr E., Hozayen Walaa G., Mohamed Hussein Aliae A.R., Elnaggar Maha Salah, Hetta Helal F.. Circulating miRNA-30a and miRNA-221 as Novel Biomarkers for the Early Detection of Non-Small-Cell Lung Cancer. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2020;11(1):50-58. Available from: https://sid.ir/paper/321317/en

    IEEE: Copy

    Soad M. Abdel Ghany, Esraa MA. Ali, Amr E. Ahmed, Walaa G. Hozayen, Aliae A.R. Mohamed Hussein, Maha Salah Elnaggar, and Helal F. Hetta, “Circulating miRNA-30a and miRNA-221 as Novel Biomarkers for the Early Detection of Non-Small-Cell Lung Cancer,” MIDDLE EAST JOURNAL OF CANCER, vol. 11, no. 1, pp. 50–58, 2020, [Online]. Available: https://sid.ir/paper/321317/en

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