ESTIMATING GLOMERULAR FILTRATION RATE IN OVERWEIGHT AND OBESE MALAYSIAN SUBJECTS

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SHAHARUDIN N.H.; ABDUL GAFOR A.H.; ZAINUDIN S.; KONG N.C.; AZIZ A.A.; SHAH SH.A.

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Journal: Nephro-Urology Monthly Year:2011 | Volume:3 | Issue:1 Page(s): 15-22

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Title

ESTIMATING GLOMERULAR FILTRATION RATE IN OVERWEIGHT AND OBESE MALAYSIAN SUBJECTS

Author(s)

Keywords

EGFR

OVERWEIGHT

OBESE

CKD

COCKCROFT-GAULT

MDRD

Abstract

Background and Aims: OVERWEIGHT and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in OVERWEIGHT and OBESE subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR.Methods: Healthy volunteers with BMI ³23kg/m² were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the EGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA. Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m2 (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m². Although the EGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects’ weight (p=0.036), it didn’t with their BMI (p=0.302).Conclusions: The MDRD-based formulae were better in estimating GFR in OVERWEIGHT and OBESE Malaysian subjects. GFR correlated with subjects’ weight rather than BMI.

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APA: Copy

SHAHARUDIN, N.H., ABDUL GAFOR, A.H., ZAINUDIN, S., KONG, N.C., AZIZ, A.A., & SHAH, SH.A.. (2011). ESTIMATING GLOMERULAR FILTRATION RATE IN OVERWEIGHT AND OBESE MALAYSIAN SUBJECTS. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 3(1), 15-22. SID. https://sid.ir/paper/323674/en

Vancouver: Copy

SHAHARUDIN N.H., ABDUL GAFOR A.H., ZAINUDIN S., KONG N.C., AZIZ A.A., SHAH SH.A.. ESTIMATING GLOMERULAR FILTRATION RATE IN OVERWEIGHT AND OBESE MALAYSIAN SUBJECTS. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2011;3(1):15-22. Available from: https://sid.ir/paper/323674/en

IEEE: Copy

N.H. SHAHARUDIN, A.H. ABDUL GAFOR, S. ZAINUDIN, N.C. KONG, A.A. AZIZ, and SH.A. SHAH, “ESTIMATING GLOMERULAR FILTRATION RATE IN OVERWEIGHT AND OBESE MALAYSIAN SUBJECTS,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 3, no. 1, pp. 15–22, 2011, [Online]. Available: https://sid.ir/paper/323674/en

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