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Title

SERONEGATIVE CELIAC DISEASE: WHERE IS THE SPECIFIC SETTING? (REVIEW ARTICLE)

Pages

  110-116

Abstract

 The DIAGNOSIS of Celiac Disease (CD) relies on the concordance of pathological, serological, genetic and clinical features. For this reason, the DIAGNOSIS of CD is often a challenge. SERONEGATIVE CELIAC DISEASE (SNCD) is defined by the negativity of anti-tissue transglutaminase antibodies in the presence of a positive histology on duodenal biopsy samples, i.e. inflammatory infiltrate of intra-epithelial lymphocytes (IELs > 25/100 enterocytes), mild villous atrophy and uneven brush border associated to human leukocyte antigen (HLA) haplotype DQ2 and/or DQ8.SNCD is characterized by mucosal deposits of TISSUE TRANSGLUTAMINASE (tTG)/anti-tTG immuno-complexes. These may counteract the passage of anti-tTG into the bloodstream, thus explaining seronegativity. Another reason for seronegativity may be found in an incomplete maturation of plasma cells with a consequent failure of antibodies production. This condition often characterizes immunoglobulin deficiencies, and, indeed, SNCD is common in subjects with immunoglobulin deficiencies.The management of SNCD still remains debated. The treatment option for SNCD may be represented by gluten free diet (GFD), but the usefulness and appropriateness of prescribing GFD are controversial. Some evidences support its use only in SNCD subjects showing CD clear clinical picture and compatible HLA status. The choice of GFD administration could be linked to an investigation able to diagnose SNCD in no doubt even if a reliable test is not currently available. On these bases, a test helping the DIAGNOSIS of SNCD is justifiable and desirable.

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    APA: Copy

    IERARDI, ENZO, LOSURDO, GIUSEPPE, PISCITELLI, DOMENICO, GIORGIO, FLORIANA, SORRENTINO, CLAUDIA, PRINCIPI, MARIABEATRICE, MONTENEGRO, LUCIA, AMORUSO, ANNACINZIA, & LEO, ALFREDO DI. (2015). SERONEGATIVE CELIAC DISEASE: WHERE IS THE SPECIFIC SETTING? (REVIEW ARTICLE). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(2), 110-116. SID. https://sid.ir/paper/324622/en

    Vancouver: Copy

    IERARDI ENZO, LOSURDO GIUSEPPE, PISCITELLI DOMENICO, GIORGIO FLORIANA, SORRENTINO CLAUDIA, PRINCIPI MARIABEATRICE, MONTENEGRO LUCIA, AMORUSO ANNACINZIA, LEO ALFREDO DI. SERONEGATIVE CELIAC DISEASE: WHERE IS THE SPECIFIC SETTING? (REVIEW ARTICLE). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(2):110-116. Available from: https://sid.ir/paper/324622/en

    IEEE: Copy

    ENZO IERARDI, GIUSEPPE LOSURDO, DOMENICO PISCITELLI, FLORIANA GIORGIO, CLAUDIA SORRENTINO, MARIABEATRICE PRINCIPI, LUCIA MONTENEGRO, ANNACINZIA AMORUSO, and ALFREDO DI LEO, “SERONEGATIVE CELIAC DISEASE: WHERE IS THE SPECIFIC SETTING? (REVIEW ARTICLE),” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 2, pp. 110–116, 2015, [Online]. Available: https://sid.ir/paper/324622/en

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