مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

175
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

149
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Evaluation of IL-17B and IL-17F mRNA expression in peripheral blood mononuclear cells and association with clinical outcome of IBD patients

Pages

  79-84

Abstract

 Aim: In this study, we determined the gene expression analysis of IL-17 gene family for early detection of subclinical inflammation among IBD patients. Background: Cytokines have a vital role in the pathogenesis of Inflammatory bowel disease (IBD). Interleukin-17 is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17F is mainly involved in mucosal host defense mechanisms whereas the functions of IL-17B remain largely elusive. Methods: In this cross-sectional study, IBD patients divided into two active and inactive groups. Peripheral blood mononuclear cells (PBMCs) from 38 IBD patients which 20 inactive samples and 18 active individuals were collected. Changes of IL-17 F and IL-17B mRNA expression level evaluated by quantitative-real time-PCR. Results: mRNA expression level of IL-17B and IL-17F in CD, UC, active and inactive groups have been assessed and there were no significant differences (P>0. 05). Patients were classified into five different categories as follows: i) 5-ASA; ii) 5-ASA + Pred; iii) 5-ASA + AZA; iv) 5-ASA + Pred + AZA; v) 5-ASA + Pred + AZA + IFX according to medication usage, expression of IL-17F and IL-17B had no differences (p>0. 05). Conclusion: Evaluation of IL-17B and IL-17F mRNA expression level illustrate no difference among active and inactive patients. Therefore, IL-17B and IL-17F are not biomarkers in an Iranian IBD patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SAFARI, MOHAMMAD TAGHI, Chaleshi, Vahid, TARBAN, PEYMAN, NOURIAN, MAHYAR, BALAII, HEDIEH, SHAHROKH, SHABNAM, & ASADZADEH AGHDAEI, HAMID. (2017). Evaluation of IL-17B and IL-17F mRNA expression in peripheral blood mononuclear cells and association with clinical outcome of IBD patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(Suppl 1), 79-84. SID. https://sid.ir/paper/324888/en

    Vancouver: Copy

    SAFARI MOHAMMAD TAGHI, Chaleshi Vahid, TARBAN PEYMAN, NOURIAN MAHYAR, BALAII HEDIEH, SHAHROKH SHABNAM, ASADZADEH AGHDAEI HAMID. Evaluation of IL-17B and IL-17F mRNA expression in peripheral blood mononuclear cells and association with clinical outcome of IBD patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(Suppl 1):79-84. Available from: https://sid.ir/paper/324888/en

    IEEE: Copy

    MOHAMMAD TAGHI SAFARI, Vahid Chaleshi, PEYMAN TARBAN, MAHYAR NOURIAN, HEDIEH BALAII, SHABNAM SHAHROKH, and HAMID ASADZADEH AGHDAEI, “Evaluation of IL-17B and IL-17F mRNA expression in peripheral blood mononuclear cells and association with clinical outcome of IBD patients,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. Suppl 1, pp. 79–84, 2017, [Online]. Available: https://sid.ir/paper/324888/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button