ANTIDEPRESSANT-LIKE EFFECT OF AQUEOUS EXTRACT FROM ROSA DAMASCENA IN MICE

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DOLATI KARIM; RAKHSHANDEH HASSAN; SHAFEI MOHAMMAD NASER

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Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2011 | Volume:1 | Issue:2 Page(s): 91-97

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Title

ANTIDEPRESSANT-LIKE EFFECT OF AQUEOUS EXTRACT FROM ROSA DAMASCENA IN MICE

Author(s)

DOLATI KARIM | RAKHSHANDEH HASSAN | SHAFEI MOHAMMAD NASER | Issue Writer Certificate

Keywords

ROSA DAMASCENA

MICE

IMMOBILITY TIME

ANTIDEPRESSANT LIKE EFFECT

Abstract

Objective: ROSA DAMASCENA mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST).Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injected intraperitoneally. After 30 min of injection, immobility and swimming times were measured and compared with control (negative control) and imipramine (positive control).Results: The results showed that low dose (15mg/kg) of extract significantly increased swimming time and decreased IMMOBILITY TIME. However, the two high doses of extract (60 and 90mg/kg) had no significant effect on these parameters.Conclusion: These results proposed antidepressant-like effect of low concentration of aqueous extract of R. damascena.

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APA: Copy

DOLATI, KARIM, RAKHSHANDEH, HASSAN, & SHAFEI, MOHAMMAD NASER. (2011). ANTIDEPRESSANT-LIKE EFFECT OF AQUEOUS EXTRACT FROM ROSA DAMASCENA IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 1(2), 91-97. SID. https://sid.ir/paper/326227/en

Vancouver: Copy

DOLATI KARIM, RAKHSHANDEH HASSAN, SHAFEI MOHAMMAD NASER. ANTIDEPRESSANT-LIKE EFFECT OF AQUEOUS EXTRACT FROM ROSA DAMASCENA IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2011;1(2):91-97. Available from: https://sid.ir/paper/326227/en

IEEE: Copy

KARIM DOLATI, HASSAN RAKHSHANDEH, and MOHAMMAD NASER SHAFEI, “ANTIDEPRESSANT-LIKE EFFECT OF AQUEOUS EXTRACT FROM ROSA DAMASCENA IN MICE,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 1, no. 2, pp. 91–97, 2011, [Online]. Available: https://sid.ir/paper/326227/en

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