EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OFROSA DAMASCENA USING FORCED SWIMMING TEST

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DOLATI KARIM; RAKHSHANDEH HASSAN; SHAFEI MOHAMMAD NASER

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Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2012 | Volume:2 | Issue:1 Page(s): 46-51

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Information Journal Paper

Title

EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OFROSA DAMASCENA USING FORCED SWIMMING TEST

Author(s)

DOLATI KARIM | RAKHSHANDEH HASSAN | SHAFEI MOHAMMAD NASER | Issue Writer Certificate

Keywords

ROSA DAMASCENA

MICE

IMMOBILITY TIME

ANTIDEPRESSANT EFFECT

ETHANOLIC EXTRACT

Abstract

Objective: ROSA DAMASCENA mill L (R. damascena) is a medicinal plant mostly known in the world for its perfume. It also has beneficial effects on stress, tension and depression. In this experiment ANTIDEPRESSANT EFFECT of ETHANOLIC EXTRACT ofR. damascena by forced swimming test (FST) was evaluated.Material and Methods: Animals received ETHANOLIC EXTRACT (15, 60 and 90 mg/kg, i.p), imipramine (15mg/kg, i.p; positive control), or saline (negative control). Thirty min post- injection, immobility and swimming times were measured and compared in the different studied groups.Results: Intraperitoneal injection of lower concentration of extract (15 mg/kg) did not change swimming and IMMOBILITY TIMEs compared to the control group. The higher concentrations of extract (60 and 90 mg/kg) significantly increased IMMOBILITY TIME and decreased swimming time. Therefore ETHANOLIC EXTRACT at tested doses had no ANTIDEPRESSANT EFFECT in this study.Conclusion: Although ETHANOLIC EXTRACT did not have ANTIDEPRESSANT EFFECT, we cannot rule out this effect altogether. In our opinion, ANTIDEPRESSANT EFFECT is masked by CNS depression effect of ETHANOLIC EXTRACT ofR. damascena.

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APA: Copy

DOLATI, KARIM, RAKHSHANDEH, HASSAN, & SHAFEI, MOHAMMAD NASER. (2012). EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OFROSA DAMASCENA USING FORCED SWIMMING TEST. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(1), 46-51. SID. https://sid.ir/paper/326235/en

Vancouver: Copy

DOLATI KARIM, RAKHSHANDEH HASSAN, SHAFEI MOHAMMAD NASER. EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OFROSA DAMASCENA USING FORCED SWIMMING TEST. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(1):46-51. Available from: https://sid.ir/paper/326235/en

IEEE: Copy

KARIM DOLATI, HASSAN RAKHSHANDEH, and MOHAMMAD NASER SHAFEI, “EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OFROSA DAMASCENA USING FORCED SWIMMING TEST,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 1, pp. 46–51, 2012, [Online]. Available: https://sid.ir/paper/326235/en

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