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Information Journal Paper

Title

ANTIOXIDANT, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOLIC EXTRACT OF PIPER BETLE LEAVES

Pages

  112-125

Abstract

 Objective: The present study was designed to evaluate the ANTIOXIDANT, ANALGESIC, and antiinflammatory activities of the methanolic extract ofPiper betle leaves (MPBL).Materials and Methods: MPBL was evaluated for ANTI-INFLAMMATORY activity using carrageenaninduced hind paw edema model. ANALGESIC activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total ANTIOXIDANT activity, scavenging of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO) as well as inhibition of total ROS generation, and assessment of reducing power were used to evaluate ANTIOXIDANT potential of MPBL.Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (p<0.05) increase in pain threshold in hot plate method whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose-dependent manner. The same ranges of doses of MPBL caused significant (p<0.05) inhibition of carrageenan-induced paw edema after 4 h in a dose-dependent manner. In DPPH, ONOO-, and total ROS scavenging method, MPBL showed good ANTIOXIDANT potentiality with the IC50 value of 16.33±1.02, 25.16±0.61, and 41.72±0.48 mg/ml, respectively with a significant (p<0.05) good reducing power.Conclusion: The findings of the study suggested that MPBL has strong ANALGESIC, ANTI-INFLAMMATORY, and ANTIOXIDANT effects, conforming the traditional use of this plant for inflammatory pain alleviation to its ANTIOXIDANT potentiality.

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    APA: Copy

    ALAMA, BADRUL, AKTER, FAHIMA, PARVIN, NAHIDA, SHARMIN PIA, RASHNA, AKTER, SHARMIN, JESMIN, CHOWDHURY, SIFATH E JAHAN, KAZI, & HAQUE, EKRAMUL. (2013). ANTIOXIDANT, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOLIC EXTRACT OF PIPER BETLE LEAVES. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 3(2), 112-125. SID. https://sid.ir/paper/326262/en

    Vancouver: Copy

    ALAMA BADRUL, AKTER FAHIMA, PARVIN NAHIDA, SHARMIN PIA RASHNA, AKTER SHARMIN, JESMIN CHOWDHURY, SIFATH E JAHAN KAZI, HAQUE EKRAMUL. ANTIOXIDANT, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOLIC EXTRACT OF PIPER BETLE LEAVES. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2013;3(2):112-125. Available from: https://sid.ir/paper/326262/en

    IEEE: Copy

    BADRUL ALAMA, FAHIMA AKTER, NAHIDA PARVIN, RASHNA SHARMIN PIA, SHARMIN AKTER, CHOWDHURY JESMIN, KAZI SIFATH E JAHAN, and EKRAMUL HAQUE, “ANTIOXIDANT, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOLIC EXTRACT OF PIPER BETLE LEAVES,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 3, no. 2, pp. 112–125, 2013, [Online]. Available: https://sid.ir/paper/326262/en

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