مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECTS OF FOENICULUM VULGARE ETHANOL EXTRACT ON OSTEOGENESIS IN HUMAN MECENCHYMAL STEM CELLS

Pages

  135-142

Abstract

 Objective: Osteoporosis or silent disease is a major bone disorder in elderly women in current century.Estrogen has an important role in OSTEOGENESIS and prevention of bone fractures. Hormone replacement therapy (HRT) is usually accompanied by such effects as breast and ovary cancers. Thus, there is an increasing demand for replacement with plant phytoestrogens. This study is focused on determining the effects ofFoeniculum vulgare extract on PROLIFERATION and OSTEOGENESIS progress in human mesenchymal stem cells.Materials and Methods: Human mesenchymal stem cells were isolated and treated with different amount of plant extracts (0.5 to 100 mg/ml). Extract cytotoxicity was measured using MTT assay. The ALKALINE PHOSPHATASE enzyme activity was measured to evaluate the differentiation progress.Results: Results of MTT assay and ALKALINE PHOSPHATASE activity showed that FOENICULUM VULGARE extract, at range of 5 to 50 mg/ml, may positively affect cell PROLIFERATION and mineralization. The most PROLIFERATION and enzyme activity were seen with dose of 5 mg/ml.Conclusions: FOENICULUM VULGARE has been used in Iranian folk medicine for many years. Our in vitro study showed thatFoeniculum vulgare extract has osteoprotective effects.

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    APA: Copy

    MAHMOUDI, ZAHRA, SOLEIMANI, MASOUD, SAIDI, ABBAS, KHAMISIPOUR, GHOLAMREZA, & AZIZSOLTANI, AREZOO. (2013). EFFECTS OF FOENICULUM VULGARE ETHANOL EXTRACT ON OSTEOGENESIS IN HUMAN MECENCHYMAL STEM CELLS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 3(2), 135-142. SID. https://sid.ir/paper/326263/en

    Vancouver: Copy

    MAHMOUDI ZAHRA, SOLEIMANI MASOUD, SAIDI ABBAS, KHAMISIPOUR GHOLAMREZA, AZIZSOLTANI AREZOO. EFFECTS OF FOENICULUM VULGARE ETHANOL EXTRACT ON OSTEOGENESIS IN HUMAN MECENCHYMAL STEM CELLS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2013;3(2):135-142. Available from: https://sid.ir/paper/326263/en

    IEEE: Copy

    ZAHRA MAHMOUDI, MASOUD SOLEIMANI, ABBAS SAIDI, GHOLAMREZA KHAMISIPOUR, and AREZOO AZIZSOLTANI, “EFFECTS OF FOENICULUM VULGARE ETHANOL EXTRACT ON OSTEOGENESIS IN HUMAN MECENCHYMAL STEM CELLS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 3, no. 2, pp. 135–142, 2013, [Online]. Available: https://sid.ir/paper/326263/en

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