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Information Journal Paper

Title

EFFECT OF NIGELLA SATIVA ON THE KIDNEY FUNCTION IN RATS

Pages

  152-158

Abstract

 Objectives: NIGELLA SATIVA (N. sativa) is an amazing herb which is used in traditional medicine for a wide range of illnesses including bronchial asthma, dysentery, gastrointestinal problems, as well as beneficial effect on blood lipids, lowering blood pressure, serum cholesterol, and triglycerides level.This study aimed to determine the toxic effect ofN. sativa powder on the KIDNEY function which was evaluated by serum urea and creatinine and through histopathological examination of KIDNEY tissue.Methods and Materials: In this study, 24 male Sprague Dawley RATs were randomly divided into four groups (six each). The RATs were kept in the separate cage with three RATs per cage. The treatment groups were given RAT pellet containingN. sativa dose at 0.01, 0.10, and 1.00 g/kg body weight which were considered as low, normal, and high dose for five weeks while control group fed with RAT chow pellet without supplementation. At the end of 35 days, the RATs were sacrificed to take the blood sample and to remove the KIDNEY organ for TOXICITY evaluation. Statistical analyses were done through one-way ANOVA using SPSS.Results: The finding revealed that there was no significant difference in serum urea of treatment groups compared with the control group. The results showed a significant decline in serum creatinine of high dose ofNigella sativa treated compared with low dose treated and control groups (p<0.05).Histopathological examination of KIDNEY tissue showed normal KIDNEY architecture with no tissue degeneration, inflammation, necrosis, and tubular dilation in all groups.Conclusion: With the evidence of normal urea and creatinine level in blood and normal KIDNEY tissue in histology examination for all treatment groups, it is suggested that there is no toxic effect on KIDNEY function ofNigella sativa at different doses for five-week period.

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    APA: Copy

    AZIZ DOLLAH, MOHAMMAD, PARHIZKAR, SAADAT, & IZWAN, MOHAMMAD. (2013). EFFECT OF NIGELLA SATIVA ON THE KIDNEY FUNCTION IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 3(2), 152-158. SID. https://sid.ir/paper/326266/en

    Vancouver: Copy

    AZIZ DOLLAH MOHAMMAD, PARHIZKAR SAADAT, IZWAN MOHAMMAD. EFFECT OF NIGELLA SATIVA ON THE KIDNEY FUNCTION IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2013;3(2):152-158. Available from: https://sid.ir/paper/326266/en

    IEEE: Copy

    MOHAMMAD AZIZ DOLLAH, SAADAT PARHIZKAR, and MOHAMMAD IZWAN, “EFFECT OF NIGELLA SATIVA ON THE KIDNEY FUNCTION IN RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 3, no. 2, pp. 152–158, 2013, [Online]. Available: https://sid.ir/paper/326266/en

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