Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

364
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

215
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EVALUATION OF ANTIBACTERIAL EFFECTS OF ZATARIA MULTIFLORA BOISS EXTRACTS AGAINST ESBL-PRODUCING KLEBSIELLA PNEUMONIAE STRAINS

Pages

  336-343

Keywords

EXTENDED-SPECTRUM-β-LACTAMASES (ESBLS) 

Abstract

 Objective: There are few therapeutic options for treatment of multidrug resistant KLEBSIELLA PNEUMONIAE isolates as a hospital infectious agent (nosocomial infection). The aim of this study was to evaluate the antibacterial activity of ZATARIA MULTIFLORA Boiss extracts against ESBL-producing KLEBSIELLA PNEUMONIAE strains.Materials and Methods: This study was conducted on 100 K. pneumoniae isolates from two hospitals in Tehran, Iran. Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and microdilution broth methods and detection of ESBL was carried out according to CLSI guidelines. The blaCTX-M-15 plasmid gene was detected by PCR and sequencing methods. Extracts susceptibility test was performed by broth microdilution method.Results: Among 100 K. pneumoniae strains, 48 (48%) were ESBL positive. In this study, fosfomycin, colistin and tigecycline were more active than other antibiotics. The existence of blaCTX-M-15 was detected in 30 (62.5%) of 48 ESBL-producing isolates. The chloroformic extract showed potent activity against ESBL-producing K. pneumoniae strains (MIC50=1.56 mg/ml and MIC90=3.12mg/ml). The MIC50 and MIC90 (The MIC50 represents the MIC value at which³50% of the isolates in a test population are inhibited and the MIC90 represents the MIC value at which³90% of the strains within a test population are inhibited) were 3.12 and 6.25 mg/ml and 6.25 and 12.5 mg/ml for methanolic and acetonic extracts, respectively.Conclusion: The incidence of ESBL-producing K. pneumoniae is very high. Therefore, detection of ESBL-producing K. pneumoniae isolates is of great importance in identifying drug resistance patterns in K. pneumoniae isolates and in control of infections. ZATARIA MULTIFLORA may have the potential to be used against multidrug resistant organisms such as clinical isolates of ESBL-producing K. pneumoniae.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    DADASHI, MASOUD, HASHEMI, ALI, ESLAMI, GITA, FALLAH, FATEMEH, GOUDARZI, HOSSEIN, ERFANIMANESH, SOROOR, & TAHERPOUR, AREZOU. (2016). EVALUATION OF ANTIBACTERIAL EFFECTS OF ZATARIA MULTIFLORA BOISS EXTRACTS AGAINST ESBL-PRODUCING KLEBSIELLA PNEUMONIAE STRAINS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(3), 336-343. SID. https://sid.ir/paper/326325/en

    Vancouver: Copy

    DADASHI MASOUD, HASHEMI ALI, ESLAMI GITA, FALLAH FATEMEH, GOUDARZI HOSSEIN, ERFANIMANESH SOROOR, TAHERPOUR AREZOU. EVALUATION OF ANTIBACTERIAL EFFECTS OF ZATARIA MULTIFLORA BOISS EXTRACTS AGAINST ESBL-PRODUCING KLEBSIELLA PNEUMONIAE STRAINS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(3):336-343. Available from: https://sid.ir/paper/326325/en

    IEEE: Copy

    MASOUD DADASHI, ALI HASHEMI, GITA ESLAMI, FATEMEH FALLAH, HOSSEIN GOUDARZI, SOROOR ERFANIMANESH, and AREZOU TAHERPOUR, “EVALUATION OF ANTIBACTERIAL EFFECTS OF ZATARIA MULTIFLORA BOISS EXTRACTS AGAINST ESBL-PRODUCING KLEBSIELLA PNEUMONIAE STRAINS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 3, pp. 336–343, 2016, [Online]. Available: https://sid.ir/paper/326325/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top