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Information Journal Paper

Title

HEPATOPROTECTIVE ACTIVITY OF MAMMEA AFRICANA ETHANOL STEM BARK EXTRACT

Pages

  248-259

Abstract

 Objective: The stem bark of MAMMEA AFRICANA Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for HEPATOPROTECTIVE potentials against paracetamol-induced liver injury in rats.Materials and Methods: The HEPATOPROTECTIVE effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), ANTIOXIDANT enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver.Results: Administration of the stem bark extract caused a significant (p<0.05 – 0.001) dose-dependent reduction of high levels of liver enzymes (ALT, AST and ALP), total cholesterol, direct and total bilirubin as well as elevation of serum levels of total protein, albumin and ANTIOXIDANT enzymes (SOD, CAT, GPx and GSH). Histology of the liver sections of extract and silymarin-treated animals showed reductions in the pathological features compared to the paracetamol-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked HEPATOPROTECTIVE effect of the stem bark extract of M. africana.Conclusion: The results show that the stem bark extract of M. africana has HEPATOPROTECTIVE potential which may be due to its ANTIOXIDANT activity.

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    APA: Copy

    OKOKON, JUDE EFIOM, BAWO, MICHAEL BURATA, & MBAGWU, HERBERT ORJI. (2016). HEPATOPROTECTIVE ACTIVITY OF MAMMEA AFRICANA ETHANOL STEM BARK EXTRACT. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(2), 248-259. SID. https://sid.ir/paper/326340/en

    Vancouver: Copy

    OKOKON JUDE EFIOM, BAWO MICHAEL BURATA, MBAGWU HERBERT ORJI. HEPATOPROTECTIVE ACTIVITY OF MAMMEA AFRICANA ETHANOL STEM BARK EXTRACT. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(2):248-259. Available from: https://sid.ir/paper/326340/en

    IEEE: Copy

    JUDE EFIOM OKOKON, MICHAEL BURATA BAWO, and HERBERT ORJI MBAGWU, “HEPATOPROTECTIVE ACTIVITY OF MAMMEA AFRICANA ETHANOL STEM BARK EXTRACT,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 2, pp. 248–259, 2016, [Online]. Available: https://sid.ir/paper/326340/en

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